Biological Activities of Lupeol

Systematic Reviews in Pharmacy,2011,2,2,96-103.
Published:Jan, 2011
Type:Review Article

Biological Activities of Lupeol

Wal P, Wal A1, Sharma G, Rai AK

Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, 1Jodhpur National University, Jhanwar Road, Jodhpur, India.

Abstract:

Pentacyclic lupane-type triterpenes, exemplified by lupeol [lup-20(29)-en-3b-ol], principally found in common fruit plants such as olive, mango, strawberry, grapes, etc., were reported to possess beneficial effects as a therapeutic and preventive agent for a range of disorders. Although lupeol exhibits an array of biological activities like anti-inflammatory and anti-arthritic activities both in in vitro and in vivo systems, extensive exploration to establish its role as a chemopreventive compound is warranted. Last 15 years have seen tremendous efforts by researchers worldwide to develop this wonderful molecule for its clinical use toward the treatment of a variety of disorders. These studies also provide insight into the mechanism of action of lupeol and suggest that it is a multi-target agent with immense anti-inflammatory potential targeting key molecular pathways which involve nuclear factor kappa B (NF-jB), cFLIP, Fas, Kras, phosphatidylinositol-3-kinase in a variety of cells. It is noteworthy that lupeol at its effective therapeutic doses exhibits no toxicity to normal cells and tissues. The perception of chemoprevention lies still in its infancy. Intervention to slow down, arrest or reverse the process of carcinogenesis by the use of either natural or synthetic substances individually or in combination therapy has emerged as a promising and pragmatic medical approach to reduce cancer risk.