Is Hypertriglyceridemia a Key Detrimental Factor or Associative Triggering Factor for Cardiovascular Abnormalities?

Systematic Reviews in Pharmacy,2012,3,1,1-3.
Published:Jan, 2012
Type:Invited Review

Is Hypertriglyceridemia a Key Detrimental Factor or Associative Triggering Factor for Cardiovascular Abnormalities?

Pitchai Balakumar, Lalita Babbar, Sanjeev Kalra1, Nanjaian Mahadevan1, Seetharaman Sritharan2, Pawan Krishan3

Department of Pharmacology, 1Institute of Pharmacy, Rajendra Institute of Technology and Sciences (RITS), Sirsa, 2Department of NDDS, Glenmark Generics Limited, Glenmark Research Centre, MIDC, Mahape, Navi Mumbai, 3Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India

Abstract:

Elevation of fasting plasma triglycerides above the normal level (150 mg/dL) is an indication of hypertriglyceridemia (borderline high, 150–199 mg/dL; high, 200-499 mg/dL; very high, above 500 mg/dL). A plethora of experimental and clinical studies evidenced a perceptible association between hypertriglyceridemia and cardiovascular disease. Hypertriglyceridmia could lead to endothelial dysfunction, atherosclerosis, hypertension, and ischemic heart disease. In addition, studies have demonstrated the myocardial susceptibility to ischemia-reperfusion injury in the hypertriglyceridemic condition. Importantly, hypertriglyceridemia alone may cause cardiovascular abnormalities like atherosclerosis even in absence of hypercholesterolemia. It is worth-mentioning that a pharmacological reduction in triglyceride levels diminishes the cardiovascular disease pathogenesis. It is a subject of contemporary interest to detail whether hypertriglyceridemia a key detrimental factor or an associative triggering factor for cardiovascular abnormalities. This review will discuss the potential role of hypertriglyceridemia in the pathogenesis of cardiovascular disorders.