Mucoadhesive Microspheres as a Controlled Drug Delivery System for Gastroretention

Systematic Reviews in Pharmacy,2012,3,1,4-14.
Published:Jan, 2012
Type:Invited Review

Mucoadhesive Microspheres as a Controlled Drug Delivery System for Gastroretention

Shadab Md, Gourav K. Singh, Alka Ahuja, Roop K.

Khar, Sanjula Baboota, Jasjeet K. Sahni, Javed Ali Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India


Context: Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short halflife are eliminated quickly from the blood circulation, require frequent dosing. To avoid this, the oral controlled release (CR) formulations have been developed in an attempt to release the drug slowly into the GIT and maintain a constant drug concentration in the serum for longer period of time. Such oral drug delivery devices have a restriction due to a short gastric retention time (GRT), a physiological limitation. Therefore, devices which prolong gastric retention by retaining the CR system in the stomach for a longer time have been developed and explored over the past couple of years. Objectives: A mucoadhesive microsphere is one potential strategy for prolonging GRT. The present review will give a comprehensive study of research done on the formulation of microspheres using mucoadhesive polymers, the in vitro evaluation techniques employed with a special discussion on recent in vivo techniques used. Results and Conclusion: Mucoadhesive microspheres interact with mucous of GIT and are considered to be localized or trapped at the adhesive site by retaining a dosage form at the site of action, or systemic delivery by retaining a formulation in intimate contact with the absorption site which may result in prolonged gastric residence time as well as improvement in intimacy of contact with underlying absorptive membrane to achieve better therapeutic performance of drugs.