Smart Drug Delivery Systems as Game Changers in Therapeutics

Systematic Reviews in Pharmacy,2013,4,1,20-25.
Published:Jan, 2013
Type:Review Article

Smart Drug Delivery Systems as Game Changers in Therapeutics

Amita Bhandari, Anantha N. Naik1, Shaila Lewis

Departments of Pharmaceutics, and 1Pharmacy Management, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India


Smart Drug Delivery Systems (SDDS) have emerged as panacea for many clinically useful drugs weighed down with toxicity. The discovery of Amphotericin B as a liposome has raised hopes and directed mammoth efforts in SDDS. The concept of manipulation of toxicity has given rise to additional significant approaches like targeting and use of physico-chemical approaches. Currently the spectrum of SDDS comprises of targeting liposomes, drug loaded biodegradable microspheres, stimuli responsive drug polymer conjugates, smart hydrogels, polymeric micellar particles, intelligent lipoprotein carriers, and nano carriers. There is a wealth of knowledge accumulated worldwide in the area of SDDS, which can be extremely beneficial to industry as well as practitioners of health care. In this article an overview of developments are reviewed.