Plant Flavonoids as Potential Source of Future Antimalarial leads
In this article, a comprehensive review on bioactive flavonoids that are abundant in medicinal and functional food (dietary) plants has been made, with special reference to antimalarial flavonoid molecules. Flavonoids have been found to exist in plants/plant medicines comprising numerous polyphenolic compounds with a wide structural diversity having pharmacological potential in diverse range of therapeutic areas. Flavonoids derived from certain dietary plants described herein have been investigated for their antimalarial effectiveness against malaria parasites, particularly Plasmodium falciparum. The biological target specificity of their antimalarial action is so interesting that they act at protein targets at molecular level other than the conventional antimalarial targets. This approach may be a basis of establishing plant flavonoids as future antimalarial leads for the development of new and potent antimalarial drug molecules.