E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling

Edy Machmud, Nina Permatasari.

Abstract
Chlorella vulgaris is one of the green microalgae that has many contents that are beneficial to humans. The bioactive component of microalgae has antimicrobial, antitumor, antioxidant, antiviral, antifungal, and anti-inflammatory activities. Moreover, these bioactive components can produce collagen, a protein that will support cell regeneration, for example, in bone remodeling. One way to increase the effectiveness of using C. vulgaris in the bone remodeling process is to formulate C. vulgaris extract in cream form. The cream is a semi-solid preparation in the form of an emulsion containing one or more drug ingredients dissolved or dispersed in a suitable base material and contains no less than 60% water. The purpose of this study was to determine the exact formulation of C. vulgaris cream extract and to measure the effect of C. vulgaris cream extract on the oral mucosa of test animals. Our research is implementing organoleptic, homogeneity, spreadability, viscosity, pH, viscosity, flow type, centrifugation, and irritation tests. The results demonstrated that cream with a concentration of 15% was better than other levels. Cream of 5%, 10%, and 15% concentration did not irritate the mucosa of the test animals. We concluded that the cream with the range concentration did not provoke any oral mucosa adverse reaction of the test animals based.

Key words: Bone remodeling; Chlorella vulgaris; Formulation; Irritation


 
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Pubmed Style

Edy Machmud, Nina Permatasari. Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling . SRP. 2020; 11(12): 6-15. doi:10.31838/srp.2020.12.2


Web Style

Edy Machmud, Nina Permatasari. Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling . http://www.sysrevpharm.org//?mno=127092 [Access: August 21, 2020]. doi:10.31838/srp.2020.12.2


AMA (American Medical Association) Style

Edy Machmud, Nina Permatasari. Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling . SRP. 2020; 11(12): 6-15. doi:10.31838/srp.2020.12.2



Vancouver/ICMJE Style

Edy Machmud, Nina Permatasari. Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling . SRP. (2020), [cited August 21, 2020]; 11(12): 6-15. doi:10.31838/srp.2020.12.2



Harvard Style

Edy Machmud, Nina Permatasari (2020) Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling . SRP, 11 (12), 6-15. doi:10.31838/srp.2020.12.2



Turabian Style

Edy Machmud, Nina Permatasari. 2020. Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling . Systematic Reviews in Pharmacy, 11 (12), 6-15. doi:10.31838/srp.2020.12.2



Chicago Style

Edy Machmud, Nina Permatasari. "Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling ." Systematic Reviews in Pharmacy 11 (2020), 6-15. doi:10.31838/srp.2020.12.2



MLA (The Modern Language Association) Style

Edy Machmud, Nina Permatasari. "Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling ." Systematic Reviews in Pharmacy 11.12 (2020), 6-15. Print. doi:10.31838/srp.2020.12.2



APA (American Psychological Association) Style

Edy Machmud, Nina Permatasari (2020) Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling . Systematic Reviews in Pharmacy, 11 (12), 6-15. doi:10.31838/srp.2020.12.2





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