E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad.

Abstract
Background
Rheumatoid arthritis (RA) is a sore public prolonged arthropathy of indefinite etiology.
Objective
To explore the sera concentrations of neopterin (NPT), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), high sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9) in RA patients.
Methods
The work involved 40 RA Iraqi patients and 40 healthy control (HC) matched by age and sex. Sera concentrations of neopterin, TNF- α, IL-1β, IL-6, MMP-9 and hs-CRP were estimated by commercially available ELISA kit.
Results
Sera concentrations of neopterin, IL-1β, IL-6, MMP-9, TNF-α and hs-CRP were importantly greater (P<0.001) in RA cases than HCs. There was an important positive link between TNF-α and IL-1β.
Conclusion
These data establish that RA cases have great concentrations of inflammatory indicators, and these values are linked with the neopterin. Current results submit a potential function of these indicators in RA pathogenesis. Furthermore, these parameters can be served as signs of illness action in the identification and therapy of RA.

Key words: Neopterin, Interleukin-6, Interleukin-1β, Rheumatoid Arthritis


 
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How to Cite this Article
Pubmed Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad. Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients. SRP. 2020; 11(12): 88-93. doi:10.31838/srp.2020.12.14


Web Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad. Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients. http://www.sysrevpharm.org//?mno=129982 [Access: August 30, 2020]. doi:10.31838/srp.2020.12.14


AMA (American Medical Association) Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad. Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients. SRP. 2020; 11(12): 88-93. doi:10.31838/srp.2020.12.14



Vancouver/ICMJE Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad. Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients. SRP. (2020), [cited August 30, 2020]; 11(12): 88-93. doi:10.31838/srp.2020.12.14



Harvard Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad (2020) Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients. SRP, 11 (12), 88-93. doi:10.31838/srp.2020.12.14



Turabian Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad. 2020. Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients. Systematic Reviews in Pharmacy, 11 (12), 88-93. doi:10.31838/srp.2020.12.14



Chicago Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad. "Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients." Systematic Reviews in Pharmacy 11 (2020), 88-93. doi:10.31838/srp.2020.12.14



MLA (The Modern Language Association) Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad. "Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients." Systematic Reviews in Pharmacy 11.12 (2020), 88-93. Print. doi:10.31838/srp.2020.12.14



APA (American Psychological Association) Style

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad (2020) Assessment Serum Levels of Neopterin, IL-6, IL-1β, hs-CRP, TNF-α and MMP 9 in Iraqi Rheumatoid Arthritis Patients. Systematic Reviews in Pharmacy, 11 (12), 88-93. doi:10.31838/srp.2020.12.14





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