E-ISSN 0976-2779 | ISSN 0975-8453
 

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Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules

Amjid Iqbal.

Abstract
It is well known that the diphosphate of ThDP is vital for the binding to the enzyme. However, this highly charged group is unsuitable for whole cell studies or pharmaceutical development, and compounds possessing it will suffer from poor bioavailability and cellular uptake. Various research groups have investigated the possibility to mimic the diphosphate with various neutral and more stable analogues without compromising too much binding affinity for the enzyme. This review discusses those efforts, which have been made to develop the identification of uncharged, chemically stable surrogates for the diphosphate linkage. Moreover, this field, is relevant not only to ThDP-dependent enzymes but also a wide range of other enzymes and proteins that bind diphosphate esters.

Key words: ThDP, ThDP dependent enzymes, Diphosphate, Diphosphate mimics, Binding, Pharmacokinetics


 
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How to Cite this Article
Pubmed Style

Amjid Iqbal. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. SRP. 2021; 12(2): 92-102. doi:10.31838/srp.2021.2.8


Web Style

Amjid Iqbal. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. http://www.sysrevpharm.org//?mno=135445 [Access: September 17, 2020]. doi:10.31838/srp.2021.2.8


AMA (American Medical Association) Style

Amjid Iqbal. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. SRP. 2021; 12(2): 92-102. doi:10.31838/srp.2021.2.8



Vancouver/ICMJE Style

Amjid Iqbal. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. SRP. (2021), [cited September 17, 2020]; 12(2): 92-102. doi:10.31838/srp.2021.2.8



Harvard Style

Amjid Iqbal (2021) Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. SRP, 12 (2), 92-102. doi:10.31838/srp.2021.2.8



Turabian Style

Amjid Iqbal. 2021. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. Systematic Reviews in Pharmacy, 12 (2), 92-102. doi:10.31838/srp.2021.2.8



Chicago Style

Amjid Iqbal. "Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules." Systematic Reviews in Pharmacy 12 (2021), 92-102. doi:10.31838/srp.2021.2.8



MLA (The Modern Language Association) Style

Amjid Iqbal. "Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules." Systematic Reviews in Pharmacy 12.2 (2021), 92-102. Print. doi:10.31838/srp.2021.2.8



APA (American Psychological Association) Style

Amjid Iqbal (2021) Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. Systematic Reviews in Pharmacy, 12 (2), 92-102. doi:10.31838/srp.2021.2.8





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