Abstract

Yunhua Ji63379, Linmeng Wang63380, Qi Xue63381, Zhirong Luo63382 and Bo Zhang63383*

Bladder cancer continues to show an increasing trend in morbidity and mortality, and recurrence of treatment and tumor invasiveness continue to be clinically problematic. Currently, plate cultivation is influenced by a single cell type and limited cell number, which makes it difficult to simulate the microenvironment of tumor cells, while the molecular and genetic instability and high costliness in the long-term culture of animal models still leaves a gap in constructing a similar microenvironment of human tissues. The aim of this work is to provide a systematic review of literature on bioprinting models of bladder cancer, to provide a systematic evaluation of the published literature based on a systematic review and meta-analysis of the preferred reporting project guidelines. A systematic evaluation of the database with composite PRISMA criteria was performed. Two authors independently conducted the search, study selection, and data curation. The literature identified 394 articles, 5 of which met the inclusion criteria. The goals of this systematic evaluation were to highlight the importance and advantages of using bioprinting in constructing bladder tumors model. And identify potential as a preclinical model for research. Lastly, discussing the challenges faced by 3D bioprinting in tumor models.