A Clinical Update on Peroxisome Proliferator-Activated Receptors
Abstract
Kumar A, Hasamnis A
The peroxisome proliferator-activated receptors (PPARs) belong to the group of nuclear receptor superfamily. There are three subtypes of these receptors, PPAR alpha, beta, and gamma. These receptors display differential tissue distribution and have specific functions. PPARs mainly regulate lipid and carbohydrate metabolism. These receptors are also involved in inflammatory process, reproduction, carcinogenesis, and other physiological processes in the body. Modulation of these receptors has wide therapeutic potential in diseases like diabetes mellitus, obesity, heart disease, atherosclerosis, cancer, inflammatory bowel disease, and many other conditions. In the last few decades, numerous agonists and antagonists of PPARs have been discovered some of which are now used in therapeutics. This review focuses mainly on the role of PPARs and their ligands under different clinical conditions.
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| Pubmed Style Kumar A, Hasamnis A. A Clinical Update on Peroxisome Proliferator-Activated Receptors. SRP. 2010; 1(2): 175-181. doi:10.4103/0975-8453.75075 Web Style Kumar A, Hasamnis A. A Clinical Update on Peroxisome Proliferator-Activated Receptors. http://www.sysrevpharm.org/?mno=302644623 [Access: March 28, 2021]. doi:10.4103/0975-8453.75075 AMA (American Medical Association) Style Kumar A, Hasamnis A. A Clinical Update on Peroxisome Proliferator-Activated Receptors. SRP. 2010; 1(2): 175-181. doi:10.4103/0975-8453.75075 Vancouver/ICMJE Style Kumar A, Hasamnis A. A Clinical Update on Peroxisome Proliferator-Activated Receptors. SRP. (2010), [cited March 28, 2021]; 1(2): 175-181. doi:10.4103/0975-8453.75075 Harvard Style Kumar A, Hasamnis A (2010) A Clinical Update on Peroxisome Proliferator-Activated Receptors. SRP, 1 (2), 175-181. doi:10.4103/0975-8453.75075 Turabian Style Kumar A, Hasamnis A. 2010. A Clinical Update on Peroxisome Proliferator-Activated Receptors. Systematic Reviews in Pharmacy, 1 (2), 175-181. doi:10.4103/0975-8453.75075 Chicago Style Kumar A, Hasamnis A. "A Clinical Update on Peroxisome Proliferator-Activated Receptors." Systematic Reviews in Pharmacy 1 (2010), 175-181. doi:10.4103/0975-8453.75075 MLA (The Modern Language Association) Style Kumar A, Hasamnis A. "A Clinical Update on Peroxisome Proliferator-Activated Receptors." Systematic Reviews in Pharmacy 1.2 (2010), 175-181. Print. doi:10.4103/0975-8453.75075 APA (American Psychological Association) Style Kumar A, Hasamnis A (2010) A Clinical Update on Peroxisome Proliferator-Activated Receptors. Systematic Reviews in Pharmacy, 1 (2), 175-181. doi:10.4103/0975-8453.75075< |
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