Abstract

Deepjyoti Saikia55888, Akash Chathamvellim55889*, Lizanne Fernandes55890, Kadambari Patil55891 and Aswathi A55892

Ankylosing Spondylitis (AS) is an aberrant inflammatory chronic disorder characterized by an inflammation to joint particularly vertebrae of spine potentially instigates them to inter-fuse. This disease is also well known as Bekhtrev disease, Bechterew’s disease or marie-strumpell disease. Symptoms such as pulmonary fibrosis, restrictive lung disease, aortitis often occur rarely and these are often misdiagnosed with some other disease condition. Although recent research and genomic studies suggests that there were many etiological factors that contributed to this disease onset and progression. Among these it’s association with HLA B-27 gene is widely researched one or established one. Several genomic studies had also revealed the association of innate immunity with ankylosing spondylitis while other studies define K. pneumoniae infection as a perpetuating factor in AS. However this association has not been fully understood. One of the interesting mechanism by which this disease progress is the co-stimulation of TNF and IL-17 (interlukin-17) and the involvement of SOX9⁺ve (SRY Box Transcription Factor 9⁺ve). The probability of occurrence of HLA-B27 gene in general population is (~8%).