A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm
Abstract
Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari.
Background: Dental caries, which becomes a serious problem caused by its harmful effects on human health and can impair quality of life. This is a chronic infectious disease with multifactorial etiological factors due to the accumulation of biofilms on the tooth surface. Citrus aurantifolia is one of the plants which have antimicrobial activity. It originates from Southeast Asia, has been used as natural remedies for dyspepsia, antiseptic, antiviral, antifungal, anthelmintic, astringent, diuretic, insect repellent, constipation, appetite stimulant, and lower cholesterol levels. In this study, the isolation of one of the active compounds from the peel of aurantifolia orange will be carried out and testing of the active biological components that play a role in the formation of Streptococcus mutans UA 159 biofilms. Methods: Citrus aurantifolia peel was extracted with methanol and fractioned by ethyl acetate, n-hexane, and water. The most active extract was purified by a combinational technic of chromatography provided the pure compound. UV, NMR, IR, and MS spectrometry were used to characterizes active biological structures. The MBIC and MBEC values are determined by adding an isolated compound to the S. mutans UA 159 biofilms. Results: The isolation results from the skin of C. aurantifolia obtained a compound that has been determined as a derivative of monoterpenoid with the formula C10H16O2 and obtained an MBEC value of 34.75% for induction time of 30 minutes. Conclusion: The antibacterial agent obtained from the monoterpenoid extracted from C. aurantifolia peel especially for the prevention of
biofilm formation has the potential to be further developed.
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| Pubmed Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari. A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm. SRP. 2020; 11(6): 1205-1210. doi:10.31838/srp.2020.6.175 Web Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari. A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm. http://www.sysrevpharm.org/?mno=138689 [Access: March 30, 2021]. doi:10.31838/srp.2020.6.175 AMA (American Medical Association) Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari. A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm. SRP. 2020; 11(6): 1205-1210. doi:10.31838/srp.2020.6.175 Vancouver/ICMJE Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari. A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm. SRP. (2020), [cited March 30, 2021]; 11(6): 1205-1210. doi:10.31838/srp.2020.6.175 Harvard Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari (2020) A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm. SRP, 11 (6), 1205-1210. doi:10.31838/srp.2020.6.175 Turabian Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari. 2020. A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm. Systematic Reviews in Pharmacy, 11 (6), 1205-1210. doi:10.31838/srp.2020.6.175 Chicago Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari. "A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm." Systematic Reviews in Pharmacy 11 (2020), 1205-1210. doi:10.31838/srp.2020.6.175 MLA (The Modern Language Association) Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari. "A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm." Systematic Reviews in Pharmacy 11.6 (2020), 1205-1210. Print. doi:10.31838/srp.2020.6.175 APA (American Psychological Association) Style Jeffrey Jeffrey, Sunarjati Sudigdoadi, Dikdik Kurnia, Mieke Hemiawati Satari (2020) A Monoterpenoid Isolated from Citrus Aurantifolia Peel and Its Potential as An Antibacterial for The Inhibition and Eradication of Streptococcus Mutans Biofilm. Systematic Reviews in Pharmacy, 11 (6), 1205-1210. doi:10.31838/srp.2020.6.175 |
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