Abstract

Iyan Sopyan, Insan Sunan K, Dolih Gozali.

Drug encapsulation in liposomes has provided an opportunity to improve therapeutic drugs mainly through changes in biodistribution and targeting of drugs to certain tissues. The role of liposomes as a drug delivery system is to provide drugs in a controlled manner, reduce toxicity, and increase the efficacy of encapsulated drugs. Although liposomes have been widely investigated in the pharmaceutical field, liposomes have problems related to stability, including particles forming aggregates and the occurrence of drug leakage in vesicles during storage. Therefore, physical stability studies are needed to ensure product integrity during storage. A number of methods were obtained to maintain liposome stability including, freeze-drying, modification with chitosan, the addition of surfactants, and incorporation with polymer gel. Therefore, this article is intended to discuss liposome stabilization and various characterization parameters as a benchmark for liposomal stability.