Abstract

Amira Belkahla76745*, Hela Cherif76746, Ghozlene Lakhoua76747, Soumaya Debbiche76748, Salma Mkaddem76749, Sihem El Aidli76750, FerdaousYengui76751 and Mohamed Ridha Charfi76752

Platinum salts are used in the treatment of various tumors and are associated with several adverse effects. Acute pancreatitis is a rare but life-threatening complication. We report a case of Drug-Induced Acute Pancreatitis (DIAP) due to cisplatin and present a systematic review focusing on clinical features and management strategies.

A systematic review was conducted using covidence, encompassing literature published from 1985 to 2024 that reported DIAP secondary to platinum salts.

Ultimately, seven studies were included, comprising six case reports and one case series, resulting in a total of 12 cases: Five due to cisplatin, six due to oxaliplatin, and one due to carboplatin. The recorded cases included seven instances of gastrointestinal cancer, as well as one case each of lung, ovarian, testicular, breast and cervical cancer. The average latency between the initiation of treatment and the onset of DIAP was 5.2 ± 2.17 days following chemotherapy.

The therapeutic decisions made included stopping chemotherapy entirely in three cases, continuing with the same drugs under strict monitoring in two cases, discontinuing only the platinum salt in four cases, and replacing it in one case.

This work underscores the importance of early recognition of rare chemotherapy-related complications such as pancreatitis.