Abstract

Amit Antil62372, Monika Dahiya62373 and Deepali Tomar62374*

A recent innovation in new drug delivery systems aims to improve the safety and efficacy of the therapeutic molecule by developing a dosage form that is easy to administer. Swallowing is more difficult for geriatrics, pediatrics, bedridden, crippled (dysphagia), and the mentally ill patients. The oral route is the most preferred route for drug administration, mainly because it has the greatest compliance factor in pediatrics and geriatrics. It is believed to be the most efficient and safe method of drug delivery. Tablets, delicate pills, and chewable gums are examples of chewable dose forms. “Chewable squares” is a lengthy piece of drug specialty equipment. Chewable tablets are palatable and should be crushed and chewed between the teeth with little or no water added prior to consumption. The purpose of chewable tablets is to provide a unit dosage form of a pharmaceutical product that can be easily administered to infants, children, or the elderly who have difficulty swallowing whole tablets. Reduced grittiness, pleasant flavor, tongue feel, appropriate bioavailability and stability are the prerequisites. Various factors such  as  flow  ability, lubricity, disintegration, organoleptic properties, compressibility, compatibility and stability influence the formulation of chewable tablets. Advantages of chewable tablet formulations include stability, palatability, precise dosage, portability, and ease of administration. Taste-masking of bitter drug candidates can be achieved through the use of sweeteners, flavoring agents, and the use of taste-masking techniques. Chewable tablets can be formulated using tableting techniques such as dry granulation, wet granulation and direct compression. Chewable dosage forms such as soft pills, tablets, gums and chewing squares have long been part of pharmacy collections.