Abstract

Fakhra Noureen, Abid Saeed Khan

Background and objectives: Diabetes mellitus is a metabolic disorder whose prevalence is rising rapidly in an alarming rate. The main objective of the study is to analyse the level of antioxidants and oxidative stress in diabetic patients among local population of Pakistan. Material and methods: This cross sectional study was conducted in Department of Pathology, Islamic International Medical College Rawalpindi during March 2019 to November 2019. For this purpose we selected the patients who were suffering from diabetes. The data was collected from 100 patients who visited the OPD of the hospital. This study is based on the local population of Pakistan, which shows the stress level in diabetic patients. Results: The data was collected from 100 patients. According to analysis of data level of antioxidant and oxidative stress is increasing in diabetic patients because cell becomes destroyed. GSH is important non-enzymatic antioxidant which helps in scavenging of free radical mechanism. According to data the levels of GSH become decreases in diabetic patients. The data pertaining in the table shows that levels of sialic acid become increases in patients. Conclusion: It is concluded that level of antioxidants in our body plays an important role. It is obvious from the presented data that a relation exists between hyperglycaemia, oxidative stress, cellular and endothelial dysfunction.