Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ?Sembada Hitam?) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia
Abstract
David Randel Christanto, Johanes C. Mose, Tetty Yuniarti, Muhammad Begawan Bestari, Prima Nanda Fauziah, Yekti Asih Purwestri, Jefferson N. Munthe
Preeclampsia is a multisystem disorder of pregnancy that contributes to morbidity and mortality worldwide. Soluble FMS-like tyrosine kinase-1 (sFlt-1) is considered as an etiologic factor of endothelial damage in preeclampsia. Imbalance of sFlt-1 and PlGF could cause failure in trophoblastic invasion and physiological remodeling of spiral artery, and ultimately placental hypoxia. This study aimed to observe anti-angiogenic properties of black rice bran on preeclampsia through measurement of sFlt-1 and PIGF. Serum was collected from pregnant women at 28-34 weeks of gestational age with preeclampsia, and normal preeclampsia as control. Level sflt-1 and PGIF was quantified with enzyme linked immunosorbent assay (ELISA). Absorbance was read at 450 nm wavelength. Extract of black rice bran has anti-angiogenic properties by significantly decreasing sFlt-1 as well as increasing PIGF in preeclampsia-induced HUVEC. This makes black rice bran a promising agent which can be further used in preeclampsia treatment.
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| Pubmed Style Christanto DR, Mose JC, Yuniarti T, Bestari MB, Fauziah PN, Purwestri YA, Munthe JN. Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia. SRP. 2021; 12(1): 1594-1597. doi:10.31838/srp.2021.1.225 Web Style Christanto DR, Mose JC, Yuniarti T, Bestari MB, Fauziah PN, Purwestri YA, Munthe JN. Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia. http://www.sysrevpharm.org/?mno=56945 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.225 AMA (American Medical Association) Style Christanto DR, Mose JC, Yuniarti T, Bestari MB, Fauziah PN, Purwestri YA, Munthe JN. Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia. SRP. 2021; 12(1): 1594-1597. doi:10.31838/srp.2021.1.225 Vancouver/ICMJE Style Christanto DR, Mose JC, Yuniarti T, Bestari MB, Fauziah PN, Purwestri YA, Munthe JN. Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia. SRP. (2021), [cited March 29, 2021]; 12(1): 1594-1597. doi:10.31838/srp.2021.1.225 Harvard Style Christanto, D. R., Mose, . J. C., Yuniarti, . T., Bestari, . M. B., Fauziah, . P. N., Purwestri, . Y. A. & Munthe, . J. N. (2021) Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia. SRP, 12 (1), 1594-1597. doi:10.31838/srp.2021.1.225 Turabian Style Christanto, David Randel, Johanes C. Mose, Tetty Yuniarti, Muhammad Begawan Bestari, Prima Nanda Fauziah, Yekti Asih Purwestri, and Jefferson N. Munthe. 2021. Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia. Systematic Reviews in Pharmacy, 12 (1), 1594-1597. doi:10.31838/srp.2021.1.225 Chicago Style Christanto, David Randel, Johanes C. Mose, Tetty Yuniarti, Muhammad Begawan Bestari, Prima Nanda Fauziah, Yekti Asih Purwestri, and Jefferson N. Munthe. "Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia." Systematic Reviews in Pharmacy 12 (2021), 1594-1597. doi:10.31838/srp.2021.1.225 MLA (The Modern Language Association) Style Christanto, David Randel, Johanes C. Mose, Tetty Yuniarti, Muhammad Begawan Bestari, Prima Nanda Fauziah, Yekti Asih Purwestri, and Jefferson N. Munthe. "Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia." Systematic Reviews in Pharmacy 12.1 (2021), 1594-1597. Print. doi:10.31838/srp.2021.1.225 APA (American Psychological Association) Style Christanto, D. R., Mose, . J. C., Yuniarti, . T., Bestari, . M. B., Fauziah, . P. N., Purwestri, . Y. A. & Munthe, . J. N. (2021) Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia. Systematic Reviews in Pharmacy, 12 (1), 1594-1597. doi:10.31838/srp.2021.1.225 |
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