Abstract

Gita Sekar Prihanti, Raden Mochammad Kelvin Katjasungkana, Bella Ruli Novitasari, Shania Rizky Amalia, Audina Nurfajriana, Sulistyo Mulyo Agustini, Hanna Cakrawati, Desy Andari

Diabetes mellitus is characterized by a hyperglycemia, characterized by increased blood sugar level and glycosylated hemoglobin (HbA1c). Hyperglycemia also produced excessive amount of Reactive Oxygen Species (ROS) which caused increased level of serum Malondialdehyde (MDA) and progressive changes in the mean amount of the pancreatic islets. Matoa bark extract is used as an antidiabetic agent containing polyphenols and flavonoids which acts as antioxidants againts Reactive Oxygen Species (ROS) and also as an ?-glucosidase enzyme inhibitors. To determine the antidiabetic effect of matoa stem bark extract on alloxan-induced Wistar rats. Experimental research design with post-test only control group design. The control group was positive, negative, and 4 treatment groups consisted of 5 experimental animals in each group for 38 days. Blood sugar and MDA are measured using a spectrophotometer. HbA1c was measured using the HPLC method. Langerhans Island was dyed HE checked using a microscope. Data were analyzed using ANOVA, Post Hoc, and Regression tests. ANOVA test results have a significant effect (p = 0,000). Post Hoc test results obtained a significant difference (p <0.05) in all treatment groups. MDA levels At a new dose of 300mg / 200gBW, there was a significant difference (p < 0.005). Matoa bark 89% to decrease blood sugar, 96.5% to decrease in HbA1c, 72% to decrease MDA, 82% to the average picture of Langerhans Island. Doses that have a significant effect have begun to appear at a dose of 300 mg / 200 gBW to the highest dose of 400 mg / 200 gBW. Matoa stem bark extract has been shown to have antidiabetic effects that affect blood sugar levels, HbA1c, MDA, and the mean of Langerhans Island allistan-induced male Wistar rats (Rattus norvegicus).