Abstract

Noora Thamer Abdulaziz, Yasser Fakri Mustafa

Despite the isolation, design, and synthesis of a high number of compounds for managing cancer, the discovery of green chemotherapeutic agents is still represented a considerable challenge for medicinal chemists. In this concern, researchers concentrated their efforts to explore novel antitumor scaffolds by studying and screening many natural and synthetic derivatives. One of the most important family of compounds is the coumarin-derived products. Many members belong to this family have shown promising antitumor attributes with an acceptable selectivity and safety. 4-Methylumbelliferone, which is ordinarily referred to as 7-hydroxy-4-methylcoumarin, and it’s based compounds have revealed encouraging properties to execute the multidrug tumor resistance, frustrate the toxic side effects of chemotherapeutic drugs, and develop the cancer phototherapy. Also, many synthetic 4-methylumbelliferone derivatives have been authenticated to have a notable antitumor attribute versus several cancer phenotypes. In this report, we screened the published data to specify the structural features of 4-methylumbelliferone-based compounds that play a defined role in their antitumor attribute. This may direct the feature studies to design and prepared new 4-methylumbelliferone derivatives with optimal activity and selectivity.