Assessment of Hypoglycemic Effect of an Oral Insulin Formulation in Chickens as an Experimental Animal Model

Abstract

Ali M Janabi, Suaad Traiji Zamil, Suhad Traiji Zamil, Hussein Abdulkadhim A

The study aims to design and evaluate oral insulin for the purpose of achieving the following criteria: effectiveness in controlling blood sugar when taking insulin orally, palatability of the oral dose characteristics in terms of shape, color, smell and taste to be acceptable, especially for children. Stability of oral insulin against intestinal metabolism achieves constant bioavailability as well as oral doses are eligible to all diabetic patients. The oral nano polymer insulin (NPI) was assessed by GC mass, FTIR, electrophoresis, melting point, fluorescence labeling, microscopy, calorimetric, albumin binding assay and hydrophobicity test. The overall in vivo findings showed that NPI had onset of action 35+15 min and 5+1.5 hr duration of action with oral efficacy of 34+4% of that for intraperitoneal (IP) route. The pharmaceutical properties were convenient for oral use

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