Abstract

Huda Muhammed Muzher, Farha A. Ali Shafi, Abdul Ameer N. Ghloub Alrekabi.

The incidence of type 2 diabetes mellitus globally increased. Genomic damage induced by oxidative stress play important role in the pathogenesis of diabetic complications. The objectives of this research are to determine whether increased blood glucose level in diabetes patients has been related with elevated levels of oxidation and DNA damage. Case –control study of (90) (Patients previously diagnosed with type 2 diabetes and 30 controls (non-diabetic apparently healthy volunteers) all participants were tested for plasma glycosylated hemoglobin (HbA1C), the DNA oxidation and genomic instability was performed by quantified of the level of 8-OHdG in urine samples and micronuclei and binucleated cells in exfoliated buccal cells respectively. The 8-OHdG contents in urine samples of diabetic patients were substantially high. However, there were non-significant differences within groups (P>0.05) The differences between8-OHdG contents in patients versus the control group were statistically significant (P<0.01) frequency of binucletied cells positive liner correlation with frequency of micronuclei strong positive correlation between frequency of micronuclei and HbA1C value. Our study points that micronuclei assay is a very valuable and noninvasive method predict genomic instability and its consequences mostly cancer in diabetes patients. Hence, clinical applications of MN assay may potentially improve the quality of administration of patients with diabetes and its complications.

How to Cite this Article

Pubmed Style Muzher HM, Shafi FAA, Alrekabi AANG. Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients. SRP. 2021; 12(1): 598-605. doi:10.31838/srp.2021.1.86 Web Style Muzher HM, Shafi FAA, Alrekabi AANG. Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients. http://www.sysrevpharm.org/?mno=41341 [Access: March 30, 2021]. doi:10.31838/srp.2021.1.86 AMA (American Medical Association) Style Muzher HM, Shafi FAA, Alrekabi AANG. Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients. SRP. 2021; 12(1): 598-605. doi:10.31838/srp.2021.1.86 Vancouver/ICMJE Style Muzher HM, Shafi FAA, Alrekabi AANG. Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients. SRP. (2021), [cited March 30, 2021]; 12(1): 598-605. doi:10.31838/srp.2021.1.86 Harvard Style Muzher, H. M., Shafi, . F. A. A. & Alrekabi, . A. A. N. G. (2021) Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients. SRP, 12 (1), 598-605. doi:10.31838/srp.2021.1.86 Turabian Style Muzher, Huda Muhammed, Farha A. Ali Shafi, and Abdul Ameer N. Ghloub Alrekabi. 2021. Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients. Systematic Reviews in Pharmacy, 12 (1), 598-605. doi:10.31838/srp.2021.1.86 Chicago Style Muzher, Huda Muhammed, Farha A. Ali Shafi, and Abdul Ameer N. Ghloub Alrekabi. "Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients." Systematic Reviews in Pharmacy 12 (2021), 598-605. doi:10.31838/srp.2021.1.86 MLA (The Modern Language Association) Style Muzher, Huda Muhammed, Farha A. Ali Shafi, and Abdul Ameer N. Ghloub Alrekabi. "Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients." Systematic Reviews in Pharmacy 12.1 (2021), 598-605. Print. doi:10.31838/srp.2021.1.86 APA (American Psychological Association) Style Muzher, H. M., Shafi, . F. A. A. & Alrekabi, . A. A. N. G. (2021) Association between Glycated Hemoglobin A1c Levels with Genomic Instability in Type 2 Diabetes Mellitus Patients. Systematic Reviews in Pharmacy, 12 (1), 598-605. doi:10.31838/srp.2021.1.86