Abstract

Rajesh Kumar Sharma58925, Junaid Tantray58926, Sourabh Kosey58927, Akhilesh Patel58928, Priya Rani58929 and Shobit Raj58931*

The goal of this study was to see whether the aqueous and ethanolic extracts of Bauhinia variegata Linn. root had any antinociceptive effects in streptozotocin (STZ)-induced diabetic rats. A diabetic animal was created by injecting STZ (60 mg/kg, intraperitoneally) once. Hot-plate test, tail-flick test, and formalin were used to determine nociceptive thresholds after five weeks of diabetes induction. Grip strength was used to determine muscle strength during diabetic neuropathic pain. We looked at total protein and blood glucose biochemical indicators to identify an oxidative stress marker, antioxidant levels in the sciatic nerve (LPO, SOD, CAT, and GSH).

In comparison to control rats, diabetic rats had significantly higher levels of nociception and hyperalgesia. Repeated treatment of Bauhinia variegata extract decreased mechanical allodynia and restored the physiological feeling of heat pain in diabetic rats, induced with streptozotocin (STZ). The extracts significantly (p<0.001) improved the diabetic rats’ lipid peroxidation status and antioxidant enzyme (superoxide dismutase, catalase) levels.