Abstract

Bhargav Kamani73541, Savankumar Chhatrola73543* and Tejas Ganatra73542

Cytoprotective agents are defined as the drugs that are used with certain types of chemotherapy to protect the body from or minimize the side effects of chemotherapy. The leaves of the Camellia sinensis plant are used to make both green and black tea. Most of the Green Tea Polyphenols (GTPs) are flavonols commonly known as catechins. Green tea and black tea flavonoids are known to protect your heart. Due to polyphenols, both green tea and black tea have anti- inflammatory, anti-oxidant, cytoprotective action in cancer and advised for consumption of same. The present study was undertaken to determine and compare the cytoprotective effectiveness of aqueous extracts of green tea and black tea. Black and green tea were procured from Amazon subjected for various in vitro Models. Here to evaluate the cytoprotective effect of black tea and green tea we used brine shrimp model, and Allium cepa model. As a part of study, we evaluated the cytoprotective potential of black and green tea using Brine shrimp model. Presence of test drug but less as compared to that control. So, it can be said that it may give protective action against toxicity of Methotrexate (MTX). In Allium cepa model, width and length of roots was observed to evaluate the cytoprotective effect. Growth in length and width of roots was observed higher in presence of test drug but less as compared to that control. So, it can be said that it may give protective action against toxicity of MTX. From the present study, it can be concluded that the aqueous extracts of black tea and green tea showed cytoprotective activity.