Comparison between Levofloxacin Based Therapy and Clarithromycin Based Therapy through 14 Days Period for H-Pylori Eradication

Abstract

Noor Thamer Abbas Alsaadi, Marwah Thamer Abbas Alsaadi, Zina Tahsin Ali

H-pylori is a pathogen that can cause infection in human in all ages worldwide, mainly considered as a chronic infection that requires a serious treatment regimens. Most guidelines advice triple therapy including proton pump inhibitor PPI, two different antibiotics for the initial attempt to eradication of H-pylori. If the infection is persistent after the first therapy trial, a quadruple therapy which include PPI, Bismuth sub-citrate and two different antibiotics is recommended for second attempt. This study was conducted in alsamawa city/ Iraq to compare the efficacy of levofloxacin versus clarithromycin in the eradication of H.pylori .it was carried out from october 2018 to march 2019. A total of 103 patients treated with one of these regimens were interviewed after treatment completion (group A –50 patients, group B –53 patients). Collected data included age, gender, chronic diseases, smoking and indication for treatment, side effects and adherence. The eradication rate obtained with clarithromycin was significantly lower than with Levofloxacin-based therapy. From our experimental work, the side effect with clarithromycin more than with levofloxacin. In Iraq as in other developing countries, almost all antibiotics are easy to get from local pharmacies even without doctor's prescription so there is a significant misuse of antibiotics, so the antibiotic resistance is higher.