Comparison Profile of Quality of Life, Phosphorylated-Tau, and Superoxide Dismutase Plasma in Women Elderly with and without Dementia

Abstract

Lisna Anisa Fitriana, Kusnandar Anggadiredja, Irma Darmawati, Lina Anisa Nasution, Linda Amalia, Slamet Rohaedi, Iwan Setiawan, Adang Suherman, I Ketut Adnyana

Accumulation of phosphorylated-tau and low levels of superoxide dismutase is associated with dementia affecting the quality of life in the elderly. This study aimed to determine differences in quality of life (QoL), phosphorylated-tau (pTAU), and superoxide dismutase (SOD) plasma in women elderly with and without dementia. The research method was a cross-sectional study. Examination of dementia using MMSE (Mini-Mental State Examination) and CDR (Clinical Dementia Rating Scale). The measure of the quality of life using the WHO-QoL questionnaire and plasma level of p-TAU and SOD using ELISA (Enzyme-linked Immunosorbent Assay). The research sample consisted of 70 women elderly mean aged 74.69 ± 9.27 years who lived in three nursing homes. Data analysis used fisher test, independent sample t-test, Mann-Whitney test, and linear regression test. The findings showed that the quality of life differed significantly in the domain of physic (p=0.001), social-relationship (p=0.002), psychological (p<0.001), environment (p<0.001), and plasma level of p-TAU (p=0.028) and SOD (p<0.001) in women elderly with and without dementia. In term of its association with dementia, p-TAU (p=0.001), SOD (p=0.003), MMSE (p=0.028), and QoL-social (p=0.176) were final model factors of dementia in women elderly. In conclusion, there are significant differences in quality of life, p-TAU, and plasma SOD between women elderly with and without dementia.

Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3