Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy
Abstract
Sri Sulistyowati, Muhammad Adrianes Bachnas, Septiana Ekasari, Agung Sari Wijayanti
Background: Cerebral palsy (CP) is one of the most feared poor outcomes in preterm birth. The strategy to decrease CP incidence is by giving antenatal magnesium sulphate (MgSO4) prior to the inevitable preterm delivery. The neuroprotective effects of MgSO4 are driven by the stimulation of magnesium on Brain-Derived Neurotrophic Factor (BDNF) production, which improves neurogenesis and neuronal resilience. The dynamics of magnesium levels in maternal serum and umbilical cord blood with BDNF levels needs further investigation.
Aim: To investigate the correlation between maternal serum and umbilical cord blood magnesium levels over the umbilical cord blood BDNF levels.
Methods: This was a study with a cross-sectional design, involving 72 patients with gestational age 28-34 weeks, who were given MgSO4 with a loading dose of 4 g followed by maintenance 1-2 g/h until birth or for a maximum 24 hour. Samples of maternal blood and premature newborn umbilical cord blood were collected immediately after delivery. The correlation between maternal serum and umbilical cord blood levels of magnesium over BDNF levels were statistically analyzed using the Spearman correlation test.
Results: There was a modest positive correlation between maternal serum magnesium and umbilical cord blood BDNF levels (r=0.367, p<0.05), and also a weak positive correlation between umbilical cord blood magnesium and BDNF levels (r=0.269, p<0.05). Other factors that showed to influence the BDNF levels were the total dose of MgSO4 (p <0,05) and preeclampsia (p <0,05).
Conclusion: The antenatal MgSO4 for neuroprotection strategy in preterm birth gives impact on the increasing production of BDNF via higher maternal and fetal magnesium serum levels, and a higher dose is supposed to give higher production.
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| Pubmed Style Sulistyowati S, Bachnas MA, Ekasari S, Wijayanti AS. Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy. SRP. 2021; 12(1): 1624-1629. doi:10.31838/srp.2021.1.231 Web Style Sulistyowati S, Bachnas MA, Ekasari S, Wijayanti AS. Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy. http://www.sysrevpharm.org/?mno=62805 [Access: March 30, 2021]. doi:10.31838/srp.2021.1.231 AMA (American Medical Association) Style Sulistyowati S, Bachnas MA, Ekasari S, Wijayanti AS. Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy. SRP. 2021; 12(1): 1624-1629. doi:10.31838/srp.2021.1.231 Vancouver/ICMJE Style Sulistyowati S, Bachnas MA, Ekasari S, Wijayanti AS. Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy. SRP. (2021), [cited March 30, 2021]; 12(1): 1624-1629. doi:10.31838/srp.2021.1.231 Harvard Style Sulistyowati, S., Bachnas, . M. A., Ekasari, . S. & Wijayanti, . A. S. (2021) Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy. SRP, 12 (1), 1624-1629. doi:10.31838/srp.2021.1.231 Turabian Style Sulistyowati, Sri, Muhammad Adrianes Bachnas, Septiana Ekasari, and Agung Sari Wijayanti. 2021. Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy. Systematic Reviews in Pharmacy, 12 (1), 1624-1629. doi:10.31838/srp.2021.1.231 Chicago Style Sulistyowati, Sri, Muhammad Adrianes Bachnas, Septiana Ekasari, and Agung Sari Wijayanti. "Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy." Systematic Reviews in Pharmacy 12 (2021), 1624-1629. doi:10.31838/srp.2021.1.231 MLA (The Modern Language Association) Style Sulistyowati, Sri, Muhammad Adrianes Bachnas, Septiana Ekasari, and Agung Sari Wijayanti. "Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy." Systematic Reviews in Pharmacy 12.1 (2021), 1624-1629. Print. doi:10.31838/srp.2021.1.231 APA (American Psychological Association) Style Sulistyowati, S., Bachnas, . M. A., Ekasari, . S. & Wijayanti, . A. S. (2021) Correlation of the Magnesium Serum Levels in Maternal and Fetal over the Fetal Brain-Derived Neurotrophic Factor (BDNF) after Antenatal Magnesium Sulphate (MgSO4) Provision in the Preterm Birth Neuroprotection Strategy. Systematic Reviews in Pharmacy, 12 (1), 1624-1629. doi:10.31838/srp.2021.1.231 |
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