Abstract

Balaram Ghosh73180, Manas Chakraborty73181* and Rabindranath Pal73182

The goal of this study is to design liposome carrier system of forskolin for the treatment of muscle relaxant that is capable of delivering the encapsulated drug over a prolonged period of time by overcoming the limitations of conventional dosage forms. Foskolin is partially water-soluble drug but has low permeability. The main objective is to improve the permeability thereby improving the bioavailability. It is prepared by thin film hydration method, using materials like non-ionic surfactants (cholesterol, soylecithin) and solvents such as chloroform and ethanol. The Fourier Transform Infrared Spectroscopy (FTIR) results revealed that there is no interaction between forskolin and excipients; all the formulations showed better encapsulation efficacy. Scanning Electron Microscopy (SEM) analysis revealed the surface morphology of forskolin-loaded liposome while dissolution studies showed prolonged drug release. On comprising all formulations, F3 showed sustained release of 98.44% up to 12 h. This may be due to the longest saturated alkyl chain and shows the highest entrapment