Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution
Abstract
Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady
This study include a spectroscopic measurements of Stavudine diffusion in cell membrane alternative model in two different polar solutions; buffer phosphate solution (Polar solution) and N-Hexane (Non-polar solution). Consistent with the standard values, a clear maximum absorption peaks at 266 nm was noted for Stavudine in buffer phosphate solution. The data also showed that the value of the extension coefficient and Êmax reduced in the non-polar medium compare to polar medium which was noted a s a part of the spectroscopic properties of Stavudine in polar and non-polar medium. Stavudine express a high stability with time in pH 7.4 .
SDS was used as a cell membranes substitute model, and the diffusion rate of Stavudine through SDS micelles solution (with a concentration of 0.2 ×10-2 M)was examined. The chemical potential was calculated which was equal to -2489.4 J mol-1which indicate the impulsiveness of the diffusion process for the compound. The results suggested that Stavudine can diffuse (in a rate constant of 0.0183 min-1) to inside micelle from the aqueous medium. Of other detected factors; the equilibrium constant for diffusion rate was detected and was equal to 2.7313.
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| Pubmed Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. 2020; 11(6): 96-100. doi:10.31838/srp.2020.6.17 Web Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. http://www.sysrevpharm.org/?mno=112584 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.17 AMA (American Medical Association) Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. 2020; 11(6): 96-100. doi:10.31838/srp.2020.6.17 Vancouver/ICMJE Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. (2020), [cited March 29, 2021]; 11(6): 96-100. doi:10.31838/srp.2020.6.17 Harvard Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady (2020) Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP, 11 (6), 96-100. doi:10.31838/srp.2020.6.17 Turabian Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. 2020. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. Systematic Reviews in Pharmacy, 11 (6), 96-100. doi:10.31838/srp.2020.6.17 Chicago Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. "Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution." Systematic Reviews in Pharmacy 11 (2020), 96-100. doi:10.31838/srp.2020.6.17 MLA (The Modern Language Association) Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. "Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution." Systematic Reviews in Pharmacy 11.6 (2020), 96-100. Print. doi:10.31838/srp.2020.6.17 APA (American Psychological Association) Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady (2020) Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. Systematic Reviews in Pharmacy, 11 (6), 96-100. doi:10.31838/srp.2020.6.17 |
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