Abstract

Torken Ahmed Hama Hasan, Zainb Sulaiman Erzaiq, Thabet Mudheher Khalaf, Mohammed Ahmed Mustafa.

Study aimed to detect the activity of phenolic compounds against the E. histolytica parasite. 20 rats divided as following; control group. Second group rat infected with (103 cyst/ml) E. histolytica. Third group infected rat were treated with (50ug/ml) phenolic for four weeks. Fourth group infected rat were treated with (50ug/ml) phenolic for four weeks. The findings demonstrated significant elevate (P < 0.05) in levels AST, ALT and MDA with significant (P < 0.05) reduce in levels of catalase in an infected rats compared with control group. The results of treated rats show non-significant (P < 0.05) changes in all parameters compare with control group when using phenolic compounds. About the histological changes, second group show degeneration of hepatocytes with thickening wall of central vein and infiltration of mono-nucleated inflammatory. After treatment by using phenolic compounds, tissues of liver appear semi-normal in third and fourth groups. So, phenolic show a high efficacy to treatment E. histolytica infection.