Abstract

Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh.

Gabapentin (GPN) is an anti-seizure drug that has also been prescribed for managing nerve pain and other ailments. However, its abuse has become an increasing concern, as it might lead to a serious health hazard. This study was therefore conducted to investigate the effects of oral administration of GPN drug on hematological blood parameters, as well as examine histological changes in vital organs of laboratory mice. Twenty female mice were obtained for the study and divided into four groups (5 mice each). The control group (G1) was maintained on a standard ration and treated orally with 1 ml of distilled water. Treatment groups; G2, G3, and G4 were administered with GPN (1, 0.5, and 0.25 mg/kg body weight, respectively) for 8 weeks. At the end of the experiment, the animals were sacrificed and the blood was collected for hematological analysis and histological examination on the liver and kidney. The results revealed that in the GPN-treated G2 (1 mg/kg body weight), a significant (p<0.05) decrease in WBC count was observed compared with the control group (G1), but the differences among the other groups were not significant. There was a significant decrease in the RBC, MCV, and MCH values, compared to the G1. Conversely, RDW, PLT, liver enzyme function and kidney parameters in all the GPN-treated groups (G2, G3, and G4) increased significantly in relation to the G1. Furthermore, the pathohistological study revealed extensive damage to the liver tissues and hepatocyte cord in the G2; moderate damage in the G3; while no obvious change was observed in the G4. Our findings indicated that the use of GPN as an anti-arthritis drug at high doses is associated with a long-term wide range of side effects in the body, and its use is therefore recommended at lower doses.

How to Cite this Article

Pubmed Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh. Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice. SRP. 2020; 11(12): 695-700. doi:10.31838/srp.2020.12.109 Web Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh. Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice. http://www.sysrevpharm.org/?mno=22851 [Access: March 29, 2021]. doi:10.31838/srp.2020.12.109 AMA (American Medical Association) Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh. Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice. SRP. 2020; 11(12): 695-700. doi:10.31838/srp.2020.12.109 Vancouver/ICMJE Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh. Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice. SRP. (2020), [cited March 29, 2021]; 11(12): 695-700. doi:10.31838/srp.2020.12.109 Harvard Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh (2020) Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice. SRP, 11 (12), 695-700. doi:10.31838/srp.2020.12.109 Turabian Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh. 2020. Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice. Systematic Reviews in Pharmacy, 11 (12), 695-700. doi:10.31838/srp.2020.12.109 Chicago Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh. "Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice." Systematic Reviews in Pharmacy 11 (2020), 695-700. doi:10.31838/srp.2020.12.109 MLA (The Modern Language Association) Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh. "Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice." Systematic Reviews in Pharmacy 11.12 (2020), 695-700. Print. doi:10.31838/srp.2020.12.109 APA (American Psychological Association) Style Jinan Mohammod Al-Zahid, Intisar Razzaq Sharba, Jinan Mahdi Ghani, Methak Alshemkh (2020) Effects of Gabapentin Drug on Hematological Parameters and Histological Structures in Female Mice. Systematic Reviews in Pharmacy, 11 (12), 695-700. doi:10.31838/srp.2020.12.109