Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia
Abstract
Hanaa Kamil Hamad
Giardia lamblia is one of most common protozoan cause diarrheas, and the most health problem in development countries worldwide. Our work aimed to assess activity and toxicity of metronidazole loaded silver nanoparticles in treatment of acute giardiasis in mice. After inoculated mice with Giardia cysts in a dose of 105 cyst for acute infection, treatments were given for eight days. Number Giardia cysts in stool were discovered. Toxicity nanoparticles was estimated by Measurement oxidative stress markers (GSH) and (MDA) in liver, kidney tissue homogenate. The results showed single therapy was better effect by silver nanoparticles, highest percentages of reduction in number of cysts Giardia lamblia of infected mice treated with silver nanoparticles combined Metronidazole. Also, combination of Ag NPs with metronidazole was the best effect to reduce the toxic effects of this chemotherapy on liver and kidney in tissue homogenate. It seemed significant elevate levels of GSH and decrease level of MDA.
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| Pubmed Style Hanaa Kamil Hamad. Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia. SRP. 2020; 11(10): 1129-1133. doi:10.31838/srp.2020.10.163 Web Style Hanaa Kamil Hamad. Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia. http://www.sysrevpharm.org/?mno=55350 [Access: March 30, 2021]. doi:10.31838/srp.2020.10.163 AMA (American Medical Association) Style Hanaa Kamil Hamad. Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia. SRP. 2020; 11(10): 1129-1133. doi:10.31838/srp.2020.10.163 Vancouver/ICMJE Style Hanaa Kamil Hamad. Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia. SRP. (2020), [cited March 30, 2021]; 11(10): 1129-1133. doi:10.31838/srp.2020.10.163 Harvard Style Hanaa Kamil Hamad (2020) Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia. SRP, 11 (10), 1129-1133. doi:10.31838/srp.2020.10.163 Turabian Style Hanaa Kamil Hamad. 2020. Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia. Systematic Reviews in Pharmacy, 11 (10), 1129-1133. doi:10.31838/srp.2020.10.163 Chicago Style Hanaa Kamil Hamad. "Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia." Systematic Reviews in Pharmacy 11 (2020), 1129-1133. doi:10.31838/srp.2020.10.163 MLA (The Modern Language Association) Style Hanaa Kamil Hamad. "Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia." Systematic Reviews in Pharmacy 11.10 (2020), 1129-1133. Print. doi:10.31838/srp.2020.10.163 APA (American Psychological Association) Style Hanaa Kamil Hamad (2020) Estimation of Activity and Toxicity of Silver Nanoparticles loaded metronidazole against Giardia Lamblia. Systematic Reviews in Pharmacy, 11 (10), 1129-1133. doi:10.31838/srp.2020.10.163 |
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