Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method
Abstract
Marwan A. Hasan, Rebwar O. Hasan, Khalid F. Al-Rawi.
A Novel, accurate, precise and sensitive reversal indirect spectrophotometric method for estimation of Atorvastatin Calcium (ATOR) has been proposed. The method is based on an oxidation of (ATOR) with of excess of KIO4 as oxidant agent. Where, the remaining of oxidant KIO4 reacts with the Para – Anisidine (P-ANS) in acidic medium, the resulting yellowish dye complex exhibit a maximum absorption at 538.0 nm, this spectrum generated revers pack at 428 nm was certified for reverse estimation. Beer's law is obeyed over the concentration range from (5-170 µg/ml) by applying univarate techniques, tow model of multivariate techniques has been applied; Central Composite Design (CCD) and Box-Benhken Design (BBD). By using multivariate techniques, ATOR was obeyed Beer's law at concentration range from (5-185µg/ ml) and (3-188µg/ ml) for (CCD) and (BBD) techniques, respectively. This method had a good accuracy (relative error RE % in the range of (±2.386%, ±2.202% and ± 0.688) good precision (relative standard deviation RSD% is better than ±2.5833%, ±2.0522% and ±1.4177), and the limit of detection (LOD) is (0.14384, 0.12617 and 0.10588 µg/ml) and the limit of quantitation (LOQ) is (0.43590, 0.38235 and 0.32085µg/ml) for univarate, (CCD) and (BBD) techniques, respectively. The method has been applied successfully for assay of Atorvastatin Calcium in pure forms and pharmaceutical preparation forms.
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| Pubmed Style Hasan MA, Hasan RO, Al-Rawi KF. Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method. SRP. 2020; 11(9): 248-259. doi:10.31838/srp.2020.9.41 Web Style Hasan MA, Hasan RO, Al-Rawi KF. Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method. http://www.sysrevpharm.org/?mno=6466 [Access: March 30, 2021]. doi:10.31838/srp.2020.9.41 AMA (American Medical Association) Style Hasan MA, Hasan RO, Al-Rawi KF. Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method. SRP. 2020; 11(9): 248-259. doi:10.31838/srp.2020.9.41 Vancouver/ICMJE Style Hasan MA, Hasan RO, Al-Rawi KF. Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method. SRP. (2020), [cited March 30, 2021]; 11(9): 248-259. doi:10.31838/srp.2020.9.41 Harvard Style Hasan, M. A., Hasan, . R. O. & Al-Rawi, . K. F. (2020) Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method. SRP, 11 (9), 248-259. doi:10.31838/srp.2020.9.41 Turabian Style Hasan, Marwan A., Rebwar O. Hasan, and Khalid F. Al-Rawi. 2020. Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method. Systematic Reviews in Pharmacy, 11 (9), 248-259. doi:10.31838/srp.2020.9.41 Chicago Style Hasan, Marwan A., Rebwar O. Hasan, and Khalid F. Al-Rawi. "Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method." Systematic Reviews in Pharmacy 11 (2020), 248-259. doi:10.31838/srp.2020.9.41 MLA (The Modern Language Association) Style Hasan, Marwan A., Rebwar O. Hasan, and Khalid F. Al-Rawi. "Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method." Systematic Reviews in Pharmacy 11.9 (2020), 248-259. Print. doi:10.31838/srp.2020.9.41 APA (American Psychological Association) Style Hasan, M. A., Hasan, . R. O. & Al-Rawi, . K. F. (2020) Evaluation and Comparison of the Optimization Parameters Based on Univariate and Multivariate Techniques for Estimation Atorvastatin Calcium with Novel Reverse Indirect Spectrophotometric Method. Systematic Reviews in Pharmacy, 11 (9), 248-259. doi:10.31838/srp.2020.9.41 |
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