Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients
Abstract
NAWRAS NAJAH MUBARK, JAFAR A. AL-MAAMORI, KAREEM HAMED GHALI
Background: Mast cells play an essential role in pathology of bronchial asthma. Stem cell factor (SCF) is a major mast cell growth factor, which could be involved in the local increase of mast cell number in the asthmatic airways when bind to its receptor (C-kit). Existing study aimed to evaluate role of gene expression of SCF and their receptor C-kit in development of bronchial asthma in Iraqi population. Methods: present study included 100 patients diagnostic with bronchial asthma (59 females and 41 males) their ages range from 2 to 61 years and 30 healthy individuals (14 females and 16 males) with the same age range as control group DNA extracted from whole blood samples and then subjected to real time PCR for detection of gene expression. Results: current data showed a significant correlation (p0.05) . The optimum cut-off values for gene expression of SCF and C-kit are ≥ 0.55, ≥2.328 respectively since there are associated with a perfect test for predicting asthma. In conclusion: high gene expression of SCF and C-kit associated with increase severity stage of bronchial asthma without treatment and can be reduced by treatment.
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| Pubmed Style MUBARK NN, AL-MAAMORI JA, GHALI KH. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. SRP. 2020; 11(1): 51-57. doi:10.5530/srp.2020.1.08 Web Style MUBARK NN, AL-MAAMORI JA, GHALI KH. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. http://www.sysrevpharm.org/?mno=302645230 [Access: March 29, 2021]. doi:10.5530/srp.2020.1.08 AMA (American Medical Association) Style MUBARK NN, AL-MAAMORI JA, GHALI KH. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. SRP. 2020; 11(1): 51-57. doi:10.5530/srp.2020.1.08 Vancouver/ICMJE Style MUBARK NN, AL-MAAMORI JA, GHALI KH. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. SRP. (2020), [cited March 29, 2021]; 11(1): 51-57. doi:10.5530/srp.2020.1.08 Harvard Style MUBARK, N. N., AL-MAAMORI, . J. A. & GHALI, . K. H. (2020) Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. SRP, 11 (1), 51-57. doi:10.5530/srp.2020.1.08 Turabian Style MUBARK, NAWRAS NAJAH, JAFAR A. AL-MAAMORI, and KAREEM HAMED GHALI. 2020. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. Systematic Reviews in Pharmacy, 11 (1), 51-57. doi:10.5530/srp.2020.1.08 Chicago Style MUBARK, NAWRAS NAJAH, JAFAR A. AL-MAAMORI, and KAREEM HAMED GHALI. "Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients." Systematic Reviews in Pharmacy 11 (2020), 51-57. doi:10.5530/srp.2020.1.08 MLA (The Modern Language Association) Style MUBARK, NAWRAS NAJAH, JAFAR A. AL-MAAMORI, and KAREEM HAMED GHALI. "Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients." Systematic Reviews in Pharmacy 11.1 (2020), 51-57. Print. doi:10.5530/srp.2020.1.08 APA (American Psychological Association) Style MUBARK, N. N., AL-MAAMORI, . J. A. & GHALI, . K. H. (2020) Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. Systematic Reviews in Pharmacy, 11 (1), 51-57. doi:10.5530/srp.2020.1.08 |
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