Abstract

Assefa Kebad Mengesha66324*

Diarrhea is defined as having three or more loose or watery stools within a 24-hour period. Using aqueous solvent fractions, n-hexane, ethyl acetate, and hydromethanolic crude extract, the study sought to evaluate the antidiarrheal properties of Acacia seyal roots in a model of diarrhea produced by castor oil. The results of this investigation showed that hydromethanolic crude extract of Acacia seyal root and solvent fractions had encouraging antidiarrheal activities in a dose-dependent manner. The findings of this study will serve as a foundation for future investigations into the structure, link between structure and activity, and mechanism of action of the biological substance that is active.