Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii)
Abstract
Vivitri Dewi Prasasty, Benedicta Haryani, Rory Anthony Hutagalung, Noryawati Mulyono, Fatmawati Yazid, Rosmalena Rosmalena, Ernawati Sinaga
Diabetes mellitus is a chronic disorder of metabolic characterized by high blood sugar levels (hyperglycemia) and glucose secretion in urine caused by lack of insulin. Hyperglycemia can cause free radical molecules formation, which can be stabilized by antioxidants. Antioxidants can be found in seaweed (e.g. red seaweed, i.e.Eucheumacottonii), which is available in large quantities in Indonesia. The purpose of this research is to determine the antioxidant and antidiabetic activities of E.cottonii extract invitro and invivo. Different solvents such as ethanol, distilled water, and warm distilled water were used for extraction. The extracts were subjected to phenolic screening, bioactive compound identification by GC-MS, antioxidant analysis using DPPH, and α-amylase activity assay in vitro and in vivo. The highest yield was obtained from warm distilled water solvent (6.8%). The phytochemical content of E. cottoniicrude extract included alkaloid, terpenoid, phenolic, flavonoid, and saponin. The highest percent inhibition on DPPH free radical scavenging and α-amylase used ethanol solvent (34.27%) and (59.33%), respectively. Male MusmusculusL. mice was used as an animal model in antidiabetic in vivo assay. Warm distilled water and ethanolic extract of E.cottoniishowed the ability to decrease BGL in diabetic mice below 100 mg/dL. Therefore, it can be concluded that the extract of red seaweed E.cottonii has the potential as an antioxidant and antidiabetic agent.
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| Pubmed Style Prasasty VD, Haryani B, Hutagalung RA, Mulyono N, Yazid F, Rosmalena R, Sinaga E. Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii). SRP. 2019; 10(1): 276-288. doi:10.5530/srp.2019.1.44 Web Style Prasasty VD, Haryani B, Hutagalung RA, Mulyono N, Yazid F, Rosmalena R, Sinaga E. Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii). http://www.sysrevpharm.org/?mno=302644999 [Access: March 29, 2021]. doi:10.5530/srp.2019.1.44 AMA (American Medical Association) Style Prasasty VD, Haryani B, Hutagalung RA, Mulyono N, Yazid F, Rosmalena R, Sinaga E. Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii). SRP. 2019; 10(1): 276-288. doi:10.5530/srp.2019.1.44 Vancouver/ICMJE Style Prasasty VD, Haryani B, Hutagalung RA, Mulyono N, Yazid F, Rosmalena R, Sinaga E. Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii). SRP. (2019), [cited March 29, 2021]; 10(1): 276-288. doi:10.5530/srp.2019.1.44 Harvard Style Prasasty, V. D., Haryani, . B., Hutagalung, . R. A., Mulyono, . N., Yazid, . F., Rosmalena, . R. & Sinaga, . E. (2019) Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii). SRP, 10 (1), 276-288. doi:10.5530/srp.2019.1.44 Turabian Style Prasasty, Vivitri Dewi, Benedicta Haryani, Rory Anthony Hutagalung, Noryawati Mulyono, Fatmawati Yazid, Rosmalena Rosmalena, and Ernawati Sinaga. 2019. Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii). Systematic Reviews in Pharmacy, 10 (1), 276-288. doi:10.5530/srp.2019.1.44 Chicago Style Prasasty, Vivitri Dewi, Benedicta Haryani, Rory Anthony Hutagalung, Noryawati Mulyono, Fatmawati Yazid, Rosmalena Rosmalena, and Ernawati Sinaga. "Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii)." Systematic Reviews in Pharmacy 10 (2019), 276-288. doi:10.5530/srp.2019.1.44 MLA (The Modern Language Association) Style Prasasty, Vivitri Dewi, Benedicta Haryani, Rory Anthony Hutagalung, Noryawati Mulyono, Fatmawati Yazid, Rosmalena Rosmalena, and Ernawati Sinaga. "Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii)." Systematic Reviews in Pharmacy 10.1 (2019), 276-288. Print. doi:10.5530/srp.2019.1.44 APA (American Psychological Association) Style Prasasty, V. D., Haryani, . B., Hutagalung, . R. A., Mulyono, . N., Yazid, . F., Rosmalena, . R. & Sinaga, . E. (2019) Evaluation of Antioxidant and Antidiabetic Activities from Red Seaweed (Eucheuma cottonii). Systematic Reviews in Pharmacy, 10 (1), 276-288. doi:10.5530/srp.2019.1.44 |
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