Abstract

Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode.

The wide uses of silver nanoparticles in the industrial, medical and cosmetic fields with it ease of entry into human body and absorption by gastrointestinal tract there for designed this study to find out the effect of silver nanoparticles on the tissue structure and functional performance of the kidney, because the process of filtering blood takes place widely in the kidney. 24 male albino rats were used for the experimental study, the rats were divided into three groups, first groups(control) dosage with normal saline solution (Injected intraperitoneal), second group (treatment) dosage with AgNPs0.75mg/kg of body weight and third group (treatment) dosage with AgNPs 1.5mg/kg of body weight. Each concentration of AgNP was dissolved in1ml of normal saline and all experimental male rats were injected via intraperitoneal with single dose /day for30 days. The resultsin this study showed tissue damage in the kidney such as vacuolar and fatty degeneration in renal tubules with pyknic nucleus in glomerulus also appear massive aggregation of mononuclear cells around blood vessels with hemorrhage and hemosiderin in renal tubules with occurrence the amyloid inside the blood vessels with necrosis in different cells associated with malfunction of kidney Shown in significant difference in urea, uric acid and creatinine when compare with control group. Histopathological changes associated with the dysfunction of the kidneys due to the effect of nanoparticles directly on the cells such as the occurrence of the reactive oxygen species (ROS) generation has key role in the events of structural and functional disorders in the kidney of male albino rats.

How to Cite this Article

Pubmed Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode. Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles. SRP. 2021; 12(3): 184-189. doi:10.31838/srp.2021.3.31 Web Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode. Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles. http://www.sysrevpharm.org/?mno=51629 [Access: March 30, 2021]. doi:10.31838/srp.2021.3.31 AMA (American Medical Association) Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode. Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles. SRP. 2021; 12(3): 184-189. doi:10.31838/srp.2021.3.31 Vancouver/ICMJE Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode. Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles. SRP. (2021), [cited March 30, 2021]; 12(3): 184-189. doi:10.31838/srp.2021.3.31 Harvard Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode (2021) Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles. SRP, 12 (3), 184-189. doi:10.31838/srp.2021.3.31 Turabian Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode. 2021. Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles. Systematic Reviews in Pharmacy, 12 (3), 184-189. doi:10.31838/srp.2021.3.31 Chicago Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode. "Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles." Systematic Reviews in Pharmacy 12 (2021), 184-189. doi:10.31838/srp.2021.3.31 MLA (The Modern Language Association) Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode. "Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles." Systematic Reviews in Pharmacy 12.3 (2021), 184-189. Print. doi:10.31838/srp.2021.3.31 APA (American Psychological Association) Style Abed HassanBaraaj, Mustafa A.K. Aitaie, Rana Hazim Hamoode (2021) Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles. Systematic Reviews in Pharmacy, 12 (3), 184-189. doi:10.31838/srp.2021.3.31