EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES
Abstract
N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina
Immune disorders arising from liver damage of various genesis, and the mechanisms of their development have still been poorly studied. The immune system functions are carried out in presence of metabolic processes and their shifts, caused by the action of various agents on the body, and liver cells – hepatocytes as well. Typical metabolic shifts that occur due to the liver damage by various toxic factors are combined with certain features of metabolic disorders in certain organs and tissues, according to the specificity of their structural and functional organization, the nature of the inducing agent and the primary sector of its effect on cells and the body as a whole. The interrelation of numerous metabolic shifts, disorders of the hepatocytes functional activity arising in such a pathology with the immune system dysfunction has not been studied enough yet, and the most effective methods of correction have not been established yet as well. At present the problems of pathogenesis, diagnosis and treatment of acute liver diseases remain the most challenging ones in medicine, both due to the complexity of diagnosis and the choice of optimal treatment methods, and due to the increasing tendency in the number of patients with these diseases. The introduction and development of cellular technologies have created serious scientific prerequisites in this area
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| Pubmed Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina. EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES. SRP. 2020; 11(12): 1391-1397. doi:10.31838/srp.2020.12.207 Web Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina. EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES. http://www.sysrevpharm.org/?mno=15844 [Access: March 28, 2021]. doi:10.31838/srp.2020.12.207 AMA (American Medical Association) Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina. EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES. SRP. 2020; 11(12): 1391-1397. doi:10.31838/srp.2020.12.207 Vancouver/ICMJE Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina. EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES. SRP. (2020), [cited March 28, 2021]; 11(12): 1391-1397. doi:10.31838/srp.2020.12.207 Harvard Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina (2020) EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES. SRP, 11 (12), 1391-1397. doi:10.31838/srp.2020.12.207 Turabian Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina. 2020. EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES. Systematic Reviews in Pharmacy, 11 (12), 1391-1397. doi:10.31838/srp.2020.12.207 Chicago Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina. "EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES." Systematic Reviews in Pharmacy 11 (2020), 1391-1397. doi:10.31838/srp.2020.12.207 MLA (The Modern Language Association) Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina. "EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES." Systematic Reviews in Pharmacy 11.12 (2020), 1391-1397. Print. doi:10.31838/srp.2020.12.207 APA (American Psychological Association) Style N.A. Konoplya, E.S. Litvinova, I.M. Kholimenko, O.N. Bushmina (2020) EXPERIMENTAL ACUTE ISCHEMIC, TOXIC AND ALCOHOL-INDUCED LIVER INJURY: RELATION OF IMMUNOLOGICAL AND METABOLIC PARAMETERS FOLLOWING THE CORRECTION WITH ALLOGENIC HEPATOCYTES. Systematic Reviews in Pharmacy, 11 (12), 1391-1397. doi:10.31838/srp.2020.12.207 |
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