Formulation and Evaluation of Floating Dosage Forms: An Overview

Abstract

Sabale V, Sakarkar SN, Pund S, Sabale PM

Floating dosage forms are emerging as a promising novel dosage forms. Floating dosage forms can be prepared as tablets, capsules by incorporating suitable excipients as well by adding certain gasgenerating agents, which in turn give the buoyancy to the dosage form in gastrointestinal fluids. The various excipients such as poloxamer 188, carbopol 934P, hydroxypropylmethylcellulose, polyethylene glycol 6000, beta-cyclodextrin, polyvinyl acetate, purified shellac, Eudragit RS, or polymethyl methacrylate, alginate beads and casein-gelatin beads in combination provide buoyancy to the dosage form. The degree of drug embedded in dosage form determines its release. The hydrated layer slowly releases the drug from the dosage form by diffusion. Due to the hydrated gel layer, floating dosage forms can remain afloat in stomach for 6-8 h and release the active pharmaceutical ingredients for extended period of time in gastric environment. These systems have more flexibility in dosage design than conventional dosage form. For the optimization of the drug release pattern in vivo, floating devices such as InteliSite capsule can be used as it provides noninvasive determination of drug absorption and bioavailability at specific sites by gamma scintigraphy. This review summarizes various techniques adopted in the development of floating dosage forms, in vitro and in vivo studies to evaluate the performance and application of floating dosage forms.

How to Cite this Article
Pubmed Style

Sabale V, Sakarkar SN, Pund S, Sabale PM. Formulation and Evaluation of Floating Dosage Forms: An Overview. SRP. 2010; 1(1): 33-39.
doi:10.4103/0975-8453.59510

Web Style

Sabale V, Sakarkar SN, Pund S, Sabale PM. Formulation and Evaluation of Floating Dosage Forms: An Overview. http://www.sysrevpharm.org/?mno=302644628 [Access: March 28, 2021]. doi:10.4103/0975-8453.59510

AMA (American Medical Association) Style

Sabale V, Sakarkar SN, Pund S, Sabale PM. Formulation and Evaluation of Floating Dosage Forms: An Overview. SRP. 2010; 1(1): 33-39. doi:10.4103/0975-8453.59510



Vancouver/ICMJE Style

Sabale V, Sakarkar SN, Pund S, Sabale PM. Formulation and Evaluation of Floating Dosage Forms: An Overview. SRP. (2010), [cited March 28, 2021]; 1(1): 33-39. doi:10.4103/0975-8453.59510



Harvard Style

Sabale V, Sakarkar SN, Pund S, Sabale PM (2010) Formulation and Evaluation of Floating Dosage Forms: An Overview. SRP, 1 (1), 33-39. doi:10.4103/0975-8453.59510



Turabian Style

Sabale V, Sakarkar SN, Pund S, Sabale PM. 2010. Formulation and Evaluation of Floating Dosage Forms: An Overview. Systematic Reviews in Pharmacy, 1 (1), 33-39. doi:10.4103/0975-8453.59510



Chicago Style

Sabale V, Sakarkar SN, Pund S, Sabale PM. "Formulation and Evaluation of Floating Dosage Forms: An Overview." Systematic Reviews in Pharmacy 1 (2010), 33-39. doi:10.4103/0975-8453.59510



MLA (The Modern Language Association) Style

Sabale V, Sakarkar SN, Pund S, Sabale PM. "Formulation and Evaluation of Floating Dosage Forms: An Overview." Systematic Reviews in Pharmacy 1.1 (2010), 33-39. Print. doi:10.4103/0975-8453.59510



APA (American Psychological Association) Style

Sabale V, Sakarkar SN, Pund S, Sabale PM (2010) Formulation and Evaluation of Floating Dosage Forms: An Overview. Systematic Reviews in Pharmacy, 1 (1), 33-39. doi:10.4103/0975-8453.59510<

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