Herpes Zoster involving the maxillary branch of the trigeminal nerve after viral vector COVID-19 vaccine: is it a possible adverse effect?

Abstract

Rebeh Bougossa47673*, Wafa Marrakchi47674, Ikbel Kooli47675, Hajer ben Brahim47676, Adnene Toumi47677, Abir Aouam47678 and Mohammed Chakroun47679

Introduction: Several vaccines against COVID-19 have been developed and approved. Many cases of Varicella-zoster virus reactivation following mRNA and inactivated COVID-19 vaccines have been described in the literature, suggesting a link between these vaccinations and the virus reactivation. However, reported cases of herpes zoster after viral vector COVID-19 vaccines were few.

Case presentation: We report a case of a maxillary zoster in a 66 year-old immunocompetent female, occurring 5 days after the first dose of a viral vector COVID-19 vaccination. The patient was treated with intravenous acyclovir for 10 days with a favourable outcome.

Conclusion: To the best of our knowledge, this is the first case of a maxillary zoster after viral vector COVID-19 vaccine. It may be a potential side effect of this vaccination. Further investigations are needed to elucidate these results.

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