Abstract

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI

Mushrooms extract have wide range of medical activity. Present study goaled to investigate healing role of P.ostrateus on aspirin induced gastric ulcer. This study carried out on rats males of Rattus norvegicus, rats divided into negative control group(C), positive control group (T1), standard drug treated control group (T2), group treated with alcoholic extract of P.ostreatus (T3),group treated with polysaccharide of P.ostreatus (T4) and group treated with chitin and chitosan of p. ostreatus (T5). Histopathological examination of stomach tissue by hematoxylin and eosin, Periodic acid Schiff and Masson's trichrome of P.ostreatus extract treated group (T3) at the end of the 10 day of treatment showed epithelial cell reconstitution and gastric cell repair in gastric mucosa accompanied with marked infiltration of leucocytes and congestion in the walls of the blood vessels of the submucosal layer. At the end of 20 days, it was observed the gastric mucosa was closely no major differences compared with normal group and had better healing effect than that of omeprazole group. Histological observation of the animals treated with Polysaccharide, Chitin and Chitosan of P.ostrateus (T5 and T4) showed moderate disruption of the surface epithelium with leucocyte infiltration and thickening of muscularis mucosae at the first period. At second period there is still mild disruption and the repair is not complete. Present study detected a significant role of P.ostreatus extract in gastric ulcer healing.

 

How to Cite this Article

Pubmed Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. SRP. 2020; 11(1): 26-34. doi:10.5530/srp.2020.1.05 Web Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. http://www.sysrevpharm.org/?mno=302645216 [Access: March 29, 2021]. doi:10.5530/srp.2020.1.05 AMA (American Medical Association) Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. SRP. 2020; 11(1): 26-34. doi:10.5530/srp.2020.1.05 Vancouver/ICMJE Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. SRP. (2020), [cited March 29, 2021]; 11(1): 26-34. doi:10.5530/srp.2020.1.05 Harvard Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI (2020) Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. SRP, 11 (1), 26-34. doi:10.5530/srp.2020.1.05 Turabian Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. 2020. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. Systematic Reviews in Pharmacy, 11 (1), 26-34. doi:10.5530/srp.2020.1.05 Chicago Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. "Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats." Systematic Reviews in Pharmacy 11 (2020), 26-34. doi:10.5530/srp.2020.1.05 MLA (The Modern Language Association) Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. "Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats." Systematic Reviews in Pharmacy 11.1 (2020), 26-34. Print. doi:10.5530/srp.2020.1.05 APA (American Psychological Association) Style MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI (2020) Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. Systematic Reviews in Pharmacy, 11 (1), 26-34. doi:10.5530/srp.2020.1.05