Abstract

Heba Sajad Al-Esawy, Oruba K. Al-bermani, Mohammed Zuhair Abdulrazzaq, Ruia Khudair Abbas

Background: The pathogenesis of Inflammatory bowel disease (IBD) is complex and remains undetermined being although to result from an interaction between susceptibility genes, bacteriology and environmental factor and immune response.
Aim: the purpose of this research is to prove the role of Clostridium difficile infection in contribution in inflammatory bowel disease onset.
Materials and methods: The current study includes 30 samples from the Ulcerative colitis (UC) and 30 samples from Crohn's disease (CD) patients. and 25 healthy persons. After endoscopy diagnosis of IBD patients by physician, 3 ml of venous blood from patients and healthy control were collected, the samples were used for immunological detections of Clostridium dificile toxin B level by ELISA method
Results: the result of the current study showed that there was highly significant concentration of toxin B of Clostridium Difficile bacteria in UC and CD plasma patients, means were (18.42 and 20.95) respectively compared with healthy control was 13.04
Conclusion: the elevated levels of C.difficile toxin B as a marker for infection with virulent strain of this bacteria considered a main cause linked with IBD occurrence