Abstract

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi

Atherosclerosis is a disorder of vasculature wall resulting mainly from the inflammatory processes. This condition involves vascular endothelial dysfunction, recruitment and activation of phagocytic cells in early stages. Omega-3 polyunsaturated fatty acids comprise part of the cellular membrane function many roles including increased development and functionality of neuronal synapses. This study assesses the significance of omega-3 fatty acids on atherosclerosis events via lowering oxidative and inflammatory insults. In this study, twenty-four domestic rabbits (male) were randomly distributed into three groups. The first one was the negative control group in which, rabbits were received normal diet (Oxide) for twelve week-period. The second group was the hypercholesteremia-induced, untreated rabbits fed with cholesterol (1%) enriched diet. The third group consumed cholesterol (1%) enriched diet supplemented with 5% omega-3 fatty acids. Blood samples were collected after twelve weeks to measure high-density lipoprotein-C (HDL-C), total cholesterol (TC), serum triglycerides (TG), endothelin-1 (ET-1), intracellular adhesion molecule-1 (ICAM-1) and highly sensitive C-reactive protein (hs-CRP) levels. After twelve weeks, aorta of each rabbit was isolated to identify glutathione (GSH),malondialdehyde (MDA) and intimal thickness. Administration of omega-3 was un-capable to modify lipid parameters significantly when compared with high cholesterol-fed rabbits. Administration of omega-3 results in improvement of ICAM-1, hs-CRP, ET-1, aortic MDA and intimal thickness of aorta significantly when compared with untreated high cholesterol-fed rabbits (P<0.05), Aortic GSH level was restored in rabbits receiving omega-3 fatty acids (P<0.05). Omega-3 fatty acid may reduce atherosclerosis progression in high cholesterol-fed rabbits via suppression of inflammatory and oxidative cascades with the lack of impacting of lipid profile.

 

How to Cite this Article

Pubmed Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. 2020; 11(5): 70-74. doi:10.31838/srp.2020.5.12 Web Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. http://www.sysrevpharm.org/?mno=106837 [Access: March 29, 2021]. doi:10.31838/srp.2020.5.12 AMA (American Medical Association) Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. 2020; 11(5): 70-74. doi:10.31838/srp.2020.5.12 Vancouver/ICMJE Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. (2020), [cited March 29, 2021]; 11(5): 70-74. doi:10.31838/srp.2020.5.12 Harvard Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi (2020) Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP, 11 (5), 70-74. doi:10.31838/srp.2020.5.12 Turabian Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. 2020. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. Systematic Reviews in Pharmacy, 11 (5), 70-74. doi:10.31838/srp.2020.5.12 Chicago Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. "Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits." Systematic Reviews in Pharmacy 11 (2020), 70-74. doi:10.31838/srp.2020.5.12 MLA (The Modern Language Association) Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. "Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits." Systematic Reviews in Pharmacy 11.5 (2020), 70-74. Print. doi:10.31838/srp.2020.5.12 APA (American Psychological Association) Style Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi (2020) Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. Systematic Reviews in Pharmacy, 11 (5), 70-74. doi:10.31838/srp.2020.5.12