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Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations

Abstract

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad.

To develop in direct colorimetric assay of pregabalin in commercial forms (capsules). This work is depend on the oxidation of pregabalin using an increasing of potassium iodate (KIO3) in presence of sulphuric acid medium is produced by the reaction of iodide ion which in turn reacts excess iodine. To release iodine and to make sure that we interact with starch we get an active complex gives maximum absorption 600nm. The calibration plot is linear in the conc. Range of 20-240 ï­g.ml-1 with amolar absorptivity is 0.239x103 l/mol.cm. The (LOD) and (LOQ) are 0.0014 and 0.0048 µg.mL-1 respectively. The proposed method can be applied for the determination of pregabalin in pure and its capsules form.

How to Cite this Article
Pubmed Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad. Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations. SRP. 2020; 11(4): 32-35. doi:10.31838/srp.2020.4.07

Web Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad. Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations. http://www.sysrevpharm.org/?mno=98597 [Access: March 29, 2021]. doi:10.31838/srp.2020.4.07

AMA (American Medical Association) Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad. Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations. SRP. 2020; 11(4): 32-35. doi:10.31838/srp.2020.4.07


Vancouver/ICMJE Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad. Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations. SRP. (2020), [cited March 29, 2021]; 11(4): 32-35. doi:10.31838/srp.2020.4.07


Harvard Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad (2020) Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations. SRP, 11 (4), 32-35. doi:10.31838/srp.2020.4.07


Turabian Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad. 2020. Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations. Systematic Reviews in Pharmacy, 11 (4), 32-35. doi:10.31838/srp.2020.4.07


Chicago Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad. "Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations." Systematic Reviews in Pharmacy 11 (2020), 32-35. doi:10.31838/srp.2020.4.07


MLA (The Modern Language Association) Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad. "Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations." Systematic Reviews in Pharmacy 11.4 (2020), 32-35. Print. doi:10.31838/srp.2020.4.07


APA (American Psychological Association) Style

Farha Khalaf Omar, Hind Ahmed Mahmoud, Nief Rahman Ahmad (2020) Indirect Spectrophotometric Method for Estimation of Pregabalin in Pharmaceutical Preparations. Systematic Reviews in Pharmacy, 11 (4), 32-35. doi:10.31838/srp.2020.4.07

 

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