Intravenous Ibuprofen for Acute Pain: Systematic Review of Randomized Controlled Trial Study

Abstract

Rizaldy Taslim Pinzon37089, Febrina Eva Susanto37090 and Tifany Edfa Suanto37091

Introduction: Acute postoperative pain still is a significant problem that occurs between 60 to 80% of patients according to the different series reported and it often remains undertreated.

Objective: This systematic review aimed to identify the benefit of Ibuprofen Intravenous in acute pain. Various methods are used to reduce pain, one of them by giving analgesics. Ibuprofen is a class of non-narcotic analgesic drugs that have antipyretic and anti-inflammatory properties.

Material and methods: The keywords used in the research process include: “Intravenous ibuprofen”. Systematic research was done using PubMed database, included study has the following criterion. Study excluded if the study was not a Randomized Controlled Trial (RCT) study, the quality of RCT was measured using the Jadad score by two appraisers.

Result: There were 674 studies related to Intravenous Ibuprofen. After screening and checking for the eligibility, remains 7 studies. All studies have a good quality indicated by Jadad score of ≥ 3. The subjects in all studies were acute pain patients and compared Intravenous (IV) Ibuprofen with another analgesia or placebo. Intravenous Ibuprofen was considered to be safe in patients with acute pain. Intravenous Ibuprofen also improves the intensity of pain in all studies.

Conclusion: Intravenous Ibuprofen proved to be effective to reduce pain among patients with acute pain compared to placebo or other NSAIDs (Non-Steroidal Anti Inflammatory Drugs), especially ketorolac. It is also found to be safe without any serious adverse event.