Abstract

Jyoti S Kolapkar, Sandip B Ahire, Vinod A Bairagi, Avinash B Gangurde

Solid Lipid Nanoparticles (SLNs) represent an advanced pharmaceutical technology designed to address challenges related to drug bioavailability and drug delivery targeting. This detailed overview delves into the various methodologies used to create SLNs, providing insights into the formulation strategies, manufacturing processes and characterization methods used throughout their development. Important topics discussed are the choice of lipid matrix, emulsification techniques and how process variables affect the physical characteristics of solid lipid nanoparticles. Furthermore, the review explores the latest advancements in SLN preparation, including novel approaches such as nano-emulsion techniques, microfluidics and alternative lipid sources. By giving a complete overview of SLN production methods, this review aims to enhance knowledge of their potential for use in drug delivery applications and pharmaceutical research.