Abstract

Hasan Dagli53921*, Özlem Gülbahar53922, Tuba Bulut53923, Mustafa Çağlar Şahin53924 and Ömer Hakan Emmez53925

Objective: Primary brain tumors are classified as glial or non-glial and benign or malignant. Meningiomas are common benign intracranial tumors. Although the name meningioma refers to a tumor of the lining of the brain called the ‘Meninx’, it has actually been shown to originate from the spider web-shaped ‘arachnoid’ membrane (arachnoid cover cells). microRNAs are 18- 22 nucleotide long, endogenous, non-protein-coding RNA molecules that negatively regulate gene expression at the post-transcriptional level. In this study, we applied a genome-wide array screen comparing the expression of miR-145, miR-34a-3p, miR-200a, miR- 335, miR-106a-5p, miR-219-5p, miR-375, miR-409-3p miR-197 and miR-224 in meningiomas.

Materials and methods: A total of 40 meningioma patients (13 men, 27 women) and healthy control individuals (12 men, 18 women) aged between 30 and 65 were inclusives in the study. The research was conducted at Gazi University Hospital.

Results: In our study, miR-197 identified as the most highly expressed miRNA in meningiomas compared to other miRNAs. miR-197, miR-34a, miR-375, miR- 219a and miR-224 stand out as potential biomarkers in human serum samples of meningiomas patients. Moreover, as per WHO classification miR-197, miR- 34a, miR-375 might be used as potential biomarkes for grade I meningioma while miR-375 for grade II meningioma.

Conclusion: The role of miRNAs in meningiomas is gaining importance each day. Therefore, our study examining the role of miRNAs in meningiomas will shed more light and pave the way for future therapeutic strategy.