IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE
Abstract
Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya.
The Complex of Cu(II)cysteinedithiocarbamate has been synthesized, it was prepared by the “in situ method” and characterized by using Ultraviolet-Visible (UV-Vis), Infra-Red (IR) spectroscopy, X-Ray Fluorescence (XRF) instruments. While melting point and conductivity also measured. The presence of UV-Vis maximum spectrums of Cu(II)cysteinedithiocarbamate at 296 nm and 436 nm indicated that electronic transition π→π* dan n→π* of CS2 and N=C=S myotis. The presence of the wavelength in the region of 399-540 cm-1 of IR spectra is indicated that has been coordination occurred between Cu(II) with Sulphur (S), Nitrogen (N), and Oxygen(O) atoms respectively from cysteinedithiocarbamate ligands. The XRF data confirm the presence of Cu and S in the new compound formed. The XRD spectrums also showed several hkl of CuO, CuS, and CuN indicating there is an interaction between Cu(II) with N, S, and O atoms. Cytotoxic test of Cu(II)cysteinedithiocarbamate complex has IC50= 639,35 µg/mL which indicates that the complex can induce the morphological MCF-7 cancer cells changes towards apoptosis.
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| Pubmed Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya. IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE. SRP. 2020; 11(9): 43-51. doi:10.31838/srp.2020.9.09 Web Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya. IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE. http://www.sysrevpharm.org/?mno=135753 [Access: March 29, 2021]. doi:10.31838/srp.2020.9.09 AMA (American Medical Association) Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya. IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE. SRP. 2020; 11(9): 43-51. doi:10.31838/srp.2020.9.09 Vancouver/ICMJE Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya. IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE. SRP. (2020), [cited March 29, 2021]; 11(9): 43-51. doi:10.31838/srp.2020.9.09 Harvard Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya (2020) IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE. SRP, 11 (9), 43-51. doi:10.31838/srp.2020.9.09 Turabian Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya. 2020. IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE. Systematic Reviews in Pharmacy, 11 (9), 43-51. doi:10.31838/srp.2020.9.09 Chicago Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya. "IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE." Systematic Reviews in Pharmacy 11 (2020), 43-51. doi:10.31838/srp.2020.9.09 MLA (The Modern Language Association) Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya. "IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE." Systematic Reviews in Pharmacy 11.9 (2020), 43-51. Print. doi:10.31838/srp.2020.9.09 APA (American Psychological Association) Style Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya (2020) IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE. Systematic Reviews in Pharmacy, 11 (9), 43-51. doi:10.31838/srp.2020.9.09 |
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