Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs)
Abstract
Akhmad Yogi Pramatirta, Anita Deborah Anwar, Sofie R. Krisnadi, Prima Nanda Fauziah, Debbie S. Retnoningrum
Preeclampsia is a multisystem disorder of pregnancy characterized by hypertension and proteinuria after 20 weeks of gestation. Trophoblast apoptosis is known to take place in preeclampsia which is regulated by cysteine aspartate specific proteases (caspase), an executor protein to assign apoptosis. To date, effective treatment for preeclampsia has not been established yet. Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular complications. In this study, we evaluated level of caspase-3 on preeclampsia induced VSMC cells performed with enzyme-linked immunosorbent assay (ELISA). Low-dose aspirin recuded apoptosis of VSMC during trophoblast invasion as indicated by lower expression of caspase-3 compared to control. Thus, aspirin is believed to reduce pro-apoptotic compounds and to compensate cells function including preeclampsia induced VSMC by controlling trophoblast apoptosis. Further studies to measure other apoptosis-related markers, as well as in vivo and clinical studies, are encouraged.
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| Pubmed Style Pramatirta AY, Anwar AD, Krisnadi SR, Fauziah PN, Retnoningrum DS. Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs). SRP. 2021; 12(1): 1551-1554. doi:10.31838/srp.2021.1.218 Web Style Pramatirta AY, Anwar AD, Krisnadi SR, Fauziah PN, Retnoningrum DS. Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs). http://www.sysrevpharm.org/?mno=52516 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.218 AMA (American Medical Association) Style Pramatirta AY, Anwar AD, Krisnadi SR, Fauziah PN, Retnoningrum DS. Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs). SRP. 2021; 12(1): 1551-1554. doi:10.31838/srp.2021.1.218 Vancouver/ICMJE Style Pramatirta AY, Anwar AD, Krisnadi SR, Fauziah PN, Retnoningrum DS. Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs). SRP. (2021), [cited March 29, 2021]; 12(1): 1551-1554. doi:10.31838/srp.2021.1.218 Harvard Style Pramatirta, A. Y., Anwar, . A. D., Krisnadi, . S. R., Fauziah, . P. N. & Retnoningrum, . D. S. (2021) Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs). SRP, 12 (1), 1551-1554. doi:10.31838/srp.2021.1.218 Turabian Style Pramatirta, Akhmad Yogi, Anita Deborah Anwar, Sofie R. Krisnadi, Prima Nanda Fauziah, and Debbie S. Retnoningrum. 2021. Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs). Systematic Reviews in Pharmacy, 12 (1), 1551-1554. doi:10.31838/srp.2021.1.218 Chicago Style Pramatirta, Akhmad Yogi, Anita Deborah Anwar, Sofie R. Krisnadi, Prima Nanda Fauziah, and Debbie S. Retnoningrum. "Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs)." Systematic Reviews in Pharmacy 12 (2021), 1551-1554. doi:10.31838/srp.2021.1.218 MLA (The Modern Language Association) Style Pramatirta, Akhmad Yogi, Anita Deborah Anwar, Sofie R. Krisnadi, Prima Nanda Fauziah, and Debbie S. Retnoningrum. "Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs)." Systematic Reviews in Pharmacy 12.1 (2021), 1551-1554. Print. doi:10.31838/srp.2021.1.218 APA (American Psychological Association) Style Pramatirta, A. Y., Anwar, . A. D., Krisnadi, . S. R., Fauziah, . P. N. & Retnoningrum, . D. S. (2021) Low-dose Aspirin Reduces Caspase-3 Expression in Maternal Preeclampsia Serum-Induced Vascular Smooth Muscle Cells (VSMCs). Systematic Reviews in Pharmacy, 12 (1), 1551-1554. doi:10.31838/srp.2021.1.218 |
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