Abstract

Gadis Meinar Sari, Soetjipto, Lilik Herawati.

Background: High-intensity physical exercise affects the increase of cortisol secretion which knows as the main glucocorticoid in the body and causes a decrease in osteoprotegerin (OPG) activity. Glucocorticoids also work directly on osteoblasts and osteocytes through glucocorticoid receptors (GRα).
Aims: this study aimed to prove the mechanism of bone metabolism disorders due to high-intensity physical exercise through changes in glucocorticoid levels, osteoprotegerin, osteocalcin, c-telopeptide and the number of apoptotic osteoblasts.
Method: an experimental study with a quasy-experimental design was used. Object used was 20 female white rats of approximately 3 months of age divided into the control and treatment groups. In the treatment group was given swimming training with 18% weight gain within 90% of the maximum time, carried out 2 times per set with a frequency of 3 times per week within 8 weeks. The data obtained were analyzed by t-test 2 independent samples and path analysis.
Result: The results of analysis showed an effect of high-intensity physical exercise on glucocorticoid levels (ɤ=0.79); glucocorticoid levels affected the level of osteoprotegerin (ɤ=-0.688) and osteocalcin (β=-0.48), however it did not affect the number of apoptotic osteoblasts (ɤ=0.21); osteoprotegerin levels affected c-telopeptide levels (β=-0.65); the number of apoptotic osteoblasts had no affected on osteocalcin levels (β=-0.19); levels of c-telopeptide (β=0.82) and osteocalcin (β=-0.22) affect the c-telopeptide or osteocalcin ratio.
Conclusion: The mechanism of bone metabolism on high-intensity physical exercise is caused by the increase of glucocorticoid levels which makes a decrease in osteoprotegerin levels and affects on the rise of c-telopeptide levels.

How to Cite this Article

Pubmed Style Sari GM, Soetjipto , Herawati L. Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise. SRP. 2020; 11(10): 836-843. doi:10.31838/srp.2020.10.125 Web Style Sari GM, Soetjipto , Herawati L. Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise. http://www.sysrevpharm.org/?mno=14910 [Access: March 29, 2021]. doi:10.31838/srp.2020.10.125 AMA (American Medical Association) Style Sari GM, Soetjipto , Herawati L. Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise. SRP. 2020; 11(10): 836-843. doi:10.31838/srp.2020.10.125 Vancouver/ICMJE Style Sari GM, Soetjipto , Herawati L. Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise. SRP. (2020), [cited March 29, 2021]; 11(10): 836-843. doi:10.31838/srp.2020.10.125 Harvard Style Sari, G. M., Soetjipto, . & Herawati, . L. (2020) Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise. SRP, 11 (10), 836-843. doi:10.31838/srp.2020.10.125 Turabian Style Sari, Gadis Meinar, Soetjipto, and Lilik Herawati. 2020. Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise. Systematic Reviews in Pharmacy, 11 (10), 836-843. doi:10.31838/srp.2020.10.125 Chicago Style Sari, Gadis Meinar, Soetjipto, and Lilik Herawati. "Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise." Systematic Reviews in Pharmacy 11 (2020), 836-843. doi:10.31838/srp.2020.10.125 MLA (The Modern Language Association) Style Sari, Gadis Meinar, Soetjipto, and Lilik Herawati. "Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise." Systematic Reviews in Pharmacy 11.10 (2020), 836-843. Print. doi:10.31838/srp.2020.10.125 APA (American Psychological Association) Style Sari, G. M., Soetjipto, . & Herawati, . L. (2020) Mechanism of Bone Metabolism Interruption Due to High Intensity Physical Exercise. Systematic Reviews in Pharmacy, 11 (10), 836-843. doi:10.31838/srp.2020.10.125