Abstract

Omar SH, Nabi Saba

Melatonin, a hormone produced primarily by the pineal gland, is also secreted from the gut and eye during darkness. There are three classes of melatonin receptors, MT1 , MT2 , and MT3 , in various regions of the human brain, gut, ovaries, and blood vessels, but most consistently found in the suprachiasmatic nucleus (SCN) of the hypothalamus and the pars tuberalis of the anterior pituitary. Melatonin has endocrine, autocrine, and paracrine actions, which are mostly receptor mediated. Primary clinical uses include the regulation of circadian rhythms and sleep disorders, although it has other endocrine, immunomodulatory, and oncostatic effects. This review summarizes the current state of melatonin research with an emphasis on its receptors, pharmacological effects, and clinical therapeutic uses.

How to Cite this Article

Pubmed Style Omar SH, Nabi Saba. Melatonin, Receptors, Mechanism, and Uses. SRP. 2010; 1(2): 158-171. doi:10.4103/0975-8453.75069 Web Style Omar SH, Nabi Saba. Melatonin, Receptors, Mechanism, and Uses. http://www.sysrevpharm.org/?mno=302644621 [Access: March 28, 2021]. doi:10.4103/0975-8453.75069 AMA (American Medical Association) Style Omar SH, Nabi Saba. Melatonin, Receptors, Mechanism, and Uses. SRP. 2010; 1(2): 158-171. doi:10.4103/0975-8453.75069 Vancouver/ICMJE Style Omar SH, Nabi Saba. Melatonin, Receptors, Mechanism, and Uses. SRP. (2010), [cited March 28, 2021]; 1(2): 158-171. doi:10.4103/0975-8453.75069 Harvard Style Omar SH, Nabi Saba (2010) Melatonin, Receptors, Mechanism, and Uses. SRP, 1 (2), 158-171. doi:10.4103/0975-8453.75069 Turabian Style Omar SH, Nabi Saba. 2010. Melatonin, Receptors, Mechanism, and Uses. Systematic Reviews in Pharmacy, 1 (2), 158-171. doi:10.4103/0975-8453.75069 Chicago Style Omar SH, Nabi Saba. "Melatonin, Receptors, Mechanism, and Uses." Systematic Reviews in Pharmacy 1 (2010), 158-171. doi:10.4103/0975-8453.75069 MLA (The Modern Language Association) Style Omar SH, Nabi Saba. "Melatonin, Receptors, Mechanism, and Uses." Systematic Reviews in Pharmacy 1.2 (2010), 158-171. Print. doi:10.4103/0975-8453.75069 APA (American Psychological Association) Style Omar SH, Nabi Saba (2010) Melatonin, Receptors, Mechanism, and Uses. Systematic Reviews in Pharmacy, 1 (2), 158-171. doi:10.4103/0975-8453.75069<